A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications

DB Kell, GJ Laubscher, E Pretorius - Biochemical Journal, 2022 - portlandpress.com
Post-acute sequelae of COVID (PASC), usually referred to as 'Long COVID'(a phenotype of
COVID-19), is a relatively frequent consequence of SARS-CoV-2 infection, in which …

The potential role of ischaemia–reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and …

DB Kell, E Pretorius - Biochemical Journal, 2022 - portlandpress.com
Ischaemia–reperfusion (I–R) injury, initiated via bursts of reactive oxygen species produced
during the reoxygenation phase following hypoxia, is well known in a variety of acute …

Co** with stress: the mitokine GDF-15 as a biomarker of COVID-19 severity

DS Ahmed, S Isnard, C Berini, J Lin, JP Routy… - Frontiers in …, 2022 - frontiersin.org
Growth differentiation factor 15 (GDF-15) is a transforming growth factor (TGF)-β superfamily
cytokine that plays a central role in metabolism regulation. Produced in response to …

[HTML][HTML] The potential role of ferroptosis in COVID-19-related cardiovascular injury

L Yang, Y Wu, W **, N Mo, G Ye, Z Su, L Tang… - Biomedicine & …, 2023 - Elsevier
COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
emerged as a global health threat in 2019. An important feature of the disease is that …

Iron status and the risk of sepsis and severe COVID-19: a two-sample Mendelian randomization study

RM Mohus, H Flatby, KV Liyanarachi, AT DeWan… - Scientific Reports, 2022 - nature.com
Observational studies have indicated an association between iron status and risk of sepsis
and COVID-19. We estimated the effect of genetically-predicted iron biomarkers on risk of …

Iron chelators: as therapeutic agents in diseases

Z Salimi, M Afsharinasab, M Rostami… - Annals of Medicine …, 2024 - journals.lww.com
The concentration of iron is tightly regulated, making it an essential element. Various cellular
processes in the body rely on iron, such as oxygen sensing, oxygen transport, electron …

[HTML][HTML] Deferiprone: a forty-year-old multi-targeting drug with possible activity against COVID-19 and diseases of similar symptomatology

GJ Kontoghiorghes - International Journal of Molecular Sciences, 2022 - mdpi.com
The need for preparing new strategies for the design of emergency drug therapies against
COVID-19 and similar diseases in the future is rather urgent, considering the high rate of …

[HTML][HTML] Overview of antiviral drug therapy for COVID-19: where do we stand?

R Esposito, D Mirra, L Sportiello, G Spaziano… - Biomedicines, 2022 - mdpi.com
The vaccine weapon has resulted in being essential in fighting the COVID-19 outbreak, but it
is not fully preventing infection due to an alarming spreading of several identified variants of …

[HTML][HTML] Thymoquinone-rich black cumin oil attenuates ibotenic acid-induced excitotoxicity through glutamate receptors in Wistar rats

SP Ittiyavirah, K Ramalingam, A Sathyan… - Saudi Pharmaceutical …, 2022 - Elsevier
Inflammation-mediated alterations in glutamate neurotransmission constitute the most
important pathway in the pathophysiology of various brain disorders. The excessive …

COVID-19-induced neurological symptoms: focus on the role of metal ions

YY Zhang, KD Ren, XJ Luo, J Peng - Inflammopharmacology, 2023 - Springer
Neurological symptoms are prevalent in both the acute and post-acute phases of
coronavirus disease 2019 (COVID-19), and they are becoming a major concern for the …