▪ Abstract Recent studies suggest that there are multiple regulatory pathways by which
chondrocytes in articular cartilage sense and respond to mechanical stimuli, including …

Articular cartilage repair and regeneration continue to be largely intractable because of the
poor regenerative properties of this tissue. The field of articular cartilage tissue engineering …

The articular cartilage has insufficient intrinsic healing abilities, and articular cartilage
injuries often progress to osteoarthritis. Alginate-based scaffolds are attractive biomaterials …

Piezo channels are mechanosensitive ion channels located in the cell membrane and
function as key cellular mechanotransducers for converting mechanical stimuli into …

The joints of mammals are lined with cartilage, comprised of individual chondrocytes
embedded in a specialized extracellular matrix. Chondrocytes experience a complex …

Articular cartilage serves as a load-bearing elastic material that is responsible for the
frictionless movement of the surfaces of articulating joints. Its ability to undergo reversible …

Hyaline cartilage, which is characterized by the absence of vascularization and innervation,
has minimal self-repair potential in case of damage and defect formation in the chondral …

Arthritis affects millions of people worldwide. With only a few disease-modifying drugs
available for treatment of rheumatoid arthritis and none for osteoarthritis, a clear need exists …

Objective Transient receptor potential vanilloid 4 (TRPV4) is a Ca2+‐permeable channel
that can be gated by tonicity (osmolarity) and mechanical stimuli. Chondrocytes, the cells in …

Objective The purpose of this paper is to review current data and concepts concerning the
effect of immobilization on articular cartilage in animal models. We also evaluate the …