The approved dose of ivermectin alone is not the ideal dose for the treatment of COVID‐19

VD Schmith, J Zhou, LRL Lohmer - Clinical Pharmacology & …, 2020 - Wiley Online Library
Caly et al. 1 reported that ivermectin inhibited severe acute respiratory syndrome‐
coronavirus 2 (SARS‐CoV‐2) in vitro for up to 48 hours using ivermectin at 5 μM. The …

[HTML][HTML] Efficacy and safety of ivermectin for treatment and prophylaxis of COVID-19 pandemic

A Elgazzar, A Eltaweel, SA Youssef, B Hany, M Hafez… - 2020 - europepmc.org
Background: Up-to-date, there is no recognized effective treatment or vaccine for the
treatment of COVID-19 that emphasize urgency around distinctive effective therapies. This …

The application of fully automated dried blood spot analysis for liquid chromatography-tandem mass spectrometry using the CAMAG DBS-MS 500 autosampler

M Luginbühl, S Gaugler - Clinical Biochemistry, 2020 - Elsevier
In the past decade, dried blood spot (DBS) sampling has been used increasingly for
microsampling in various fields. This is predominantly driven by the significant advantages …

Drug repurposing: a review of old and new antibiotics for the treatment of malaria: identifying antibiotics with a fast onset of antiplasmodial action

L Pessanha de Carvalho, A Kreidenweiss, J Held - Molecules, 2021 - mdpi.com
Malaria is one of the most life-threatening infectious diseases and constitutes a major health
problem, especially in Africa. Although artemisinin combination therapies remain efficacious …

[HTML][HTML] High-dose ivermectin for early treatment of COVID-19 (COVER study): a randomised, double-blind, multicentre, phase II, dose-finding, proof-of-concept …

D Buonfrate, F Chesini, D Martini… - International journal of …, 2022 - Elsevier
High concentrations of ivermectin demonstrated antiviral activity against SARS-CoV-2 in
vitro. The aim of this study was to assess the safety and efficacy of high-dose ivermectin in …

Pharmacokinetic considerations on the repurposing of ivermectin for treatment of COVID‐19

R Peña‐Silva, SB Duffull, AC Steer… - British journal of …, 2020 - pmc.ncbi.nlm.nih.gov
Hundreds of researchers are working to develop a vaccine and are evaluating drugs to
mitigate the adverse health and economic consequences of COVID-19 (Coronavirus …

Ivermectin therapy for young children with scabies infection: a multicentre phase 2 non-randomized trial

A Gwee, A Steer, K Phongluxa… - The Lancet Regional …, 2024 - thelancet.com
Background Ivermectin, an effective treatment for scabies, is not licensed for children
weighing< 15 kg. Pharmacokinetic modelling has shown a 3 mg dose in young children (2 …

Pharmacokinetics of ivermectin metabolites and their activity against Anopheles stephensi mosquitoes

C Kern, P Müller, C Chaccour, ME Liechti, F Hammann… - Malaria journal, 2023 - Springer
Abstract Background Ivermectin (22, 23-dihydroavermectin B1a: H2B1a) is an endectocide
used to treat worm infections and ectoparasites including lice and scabies mites …

Fully automated dried blood spot extraction coupled to liquid chromatography-tandem mass spectrometry for therapeutic drug monitoring of immunosuppressants

S Deprez, CP Stove - Journal of Chromatography A, 2021 - Elsevier
Patients receiving immunosuppressant therapy, require intensive follow-up via therapeutic
drug monitoring (TDM). This puts quite a burden on the patient involving frequent hospital …

Dried blood spots—A platform for therapeutic drug monitoring (TDM) and drug/disease response monitoring (DRM)

NNB Zailani, PCL Ho - European journal of drug metabolism and …, 2023 - Springer
This review provides an overview on the current applications of dried blood spots (DBS) as
matrices for therapeutic drug (TDM) and drug or disease response monitoring (DRM) …