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CLC chloride channels and transporters: structure, function, physiology, and disease
CLC anion transporters are found in all phyla and form a gene family of eight members in
mammals. Two CLC proteins, each of which completely contains an ion translocation …
mammals. Two CLC proteins, each of which completely contains an ion translocation …
Molecular structure and physiological function of chloride channels
Cl− channels reside both in the plasma membrane and in intracellular organelles. Their
functions range from ion homeostasis to cell volume regulation, transepithelial transport, and …
functions range from ion homeostasis to cell volume regulation, transepithelial transport, and …
Hereditary causes of kidney stones and chronic kidney disease
Adenine phosphoribosyltransferase (APRT) deficiency, cystinuria, Dent disease, familial
hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC), and primary …
hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC), and primary …
Boron based anion receptors as sensors
This critical review will explore some of the recent research into the use of boron based
anion receptors and focus on those receptors that have been designed to transduce the …
anion receptors and focus on those receptors that have been designed to transduce the …
ClC-5 Cl--channel disruption impairs endocytosis in a mouse model for Dent's disease
Dent's disease is an X-linked disorder associated with the urinary loss of low-molecular-
weight proteins, phosphate and calcium, which often leads to kidney stones,. It is caused by …
weight proteins, phosphate and calcium, which often leads to kidney stones,. It is caused by …
Renal Vacuolar H+-ATPase
Vacuolar H+-ATPases are ubiquitous multisubunit complexes mediating the ATP-dependent
transport of protons. In addition to their role in acidifying the lumen of various intracellular …
transport of protons. In addition to their role in acidifying the lumen of various intracellular …
Ion channel diseases
Ion channels serve many functions apart from electrical signal transduction: chemical
signalling (Ca2+ as a second messenger), transepithelial transport, regulation of …
signalling (Ca2+ as a second messenger), transepithelial transport, regulation of …
Chloride in vesicular trafficking and function
Luminal acidification is of pivotal importance for the physiology of the secretory and
endocytic pathways and its diverse trafficking events. Acidification by the proton-pum** V …
endocytic pathways and its diverse trafficking events. Acidification by the proton-pum** V …
Dent's disease
Dent's disease is a renal tubular disorder characterized by manifestations of proximal tubule
dysfunction, including low-molecular-weight proteinuria, hypercalciuria, nephrolithiasis …
dysfunction, including low-molecular-weight proteinuria, hypercalciuria, nephrolithiasis …
CLC chloride channels and transporters: from genes to protein structure, pathology and physiology
ABSTRACT CLC genes are expressed in species from bacteria to human and encode Cl−-
channels or Cl−/H+-exchangers. CLC proteins assemble to dimers, with each monomer …
channels or Cl−/H+-exchangers. CLC proteins assemble to dimers, with each monomer …