Matrix metalloproteinases (MMPs) have long been associated with cancer-cell invasion and
metastasis. This provided the rationale for clinical trials of MMP inhibitors, unfortunately with …

▪ Abstract The matrix metalloproteinases (MMPs) constitute a multigene family of over 25
secreted and cell surface enzymes that process or degrade numerous pericellular …

CD44 is a cell surface adhesion receptor that is highly expressed in many cancers and
regulates metastasis via recruitment of CD44 to the cell surface. Its interaction with …

We have uncovered a novel functional relationship between the hyaluronan receptor CD44,
the matrix metalloproteinase-9 (MMP-9) and the multifunctional cytokine TGF-β in the control …

Hyaluronan is an extracellular and cell-surface-associated polysaccharide that is
traditionally regarded as a biological'goo'that participates in lubricating joints or holding …

Functions of individual matrix metalloproteinases (MMPs) differentially expressed by tumor
cells and stromal cells, are finely regulated by their spatial as well as temporal interactions …

Can an abundantly expressed molecule be a reliable marker for the cancer-initiating cells
(CICs; also known as cancer stem cells), which constitute the minority of cells within the …

Matrix metalloproteinases (MMPs) are a growing family of metalloendopeptidases that
cleave the protein components of the extracellular matrix and thereby play a central role in …

Recent research has highlighted the fundamental role of the tumour's extracellular metabolic
microenvironment in malignant invasion. This microenvironment is acidified primarily by the …

This review focuses on matrix metalloproteinases (MMPs)-2 (gelatinase A) and-9
(gelatinase B), both of which are cancer-associated, secreted, zinc-dependent …