Automated data-adaptive analytics for electronic healthcare data to study causal treatment effects
S Schneeweiss - Clinical epidemiology, 2018 - Taylor & Francis
Background Decision makers in health care increasingly rely on nonrandomized database
analyses to assess the effectiveness, safety, and value of medical products. Health care data …
analyses to assess the effectiveness, safety, and value of medical products. Health care data …
Transparency and reproducibility of observational cohort studies using large healthcare databases.
SV Wang, P Verpillat, JA Rassen… - Clinical …, 2016 - Wiley Online Library
The scientific community and decision‐makers are increasingly concerned about
transparency and reproducibility of epidemiologic studies using longitudinal healthcare …
transparency and reproducibility of epidemiologic studies using longitudinal healthcare …
Assessing the benefits and harms of pharmacotherapy in older adults with frailty: insights from pharmacoepidemiologic studies of routine health care data
The objective of this review is to summarize and appraise the research methodology,
emerging findings, and future directions in pharmacoepidemiologic studies assessing the …
emerging findings, and future directions in pharmacoepidemiologic studies assessing the …
Relative performance of propensity score matching strategies for subgroup analyses
Postapproval drug safety studies often use propensity scores (PSs) to adjust for a large
number of baseline confounders. These studies may involve examining whether treatment …
number of baseline confounders. These studies may involve examining whether treatment …
Real world data in adaptive biomedical innovation: a framework for generating evidence fit for decision‐making
S Schneeweiss, HG Eichler… - Clinical …, 2016 - Wiley Online Library
Analyses of healthcare databases (claims, electronic health records [EHRs]) are useful
supplements to clinical trials for generating evidence on the effectiveness, harm, use, and …
supplements to clinical trials for generating evidence on the effectiveness, harm, use, and …
The State of Use and Utility of Negative Controls in Pharmacoepidemiologic Studies
Uses of real-world data in drug safety and effectiveness studies are often challenged by
various sources of bias. We undertook a systematic search of the published literature …
various sources of bias. We undertook a systematic search of the published literature …
Successful comparison of US Food and Drug Administration sentinel analysis tools to traditional approaches in quantifying a known drug‐adverse event association
The US Food and Drug Administration's Sentinel system has developed the capability to
conduct active safety surveillance of marketed medical products in a large network of …
conduct active safety surveillance of marketed medical products in a large network of …
Prospective postmarketing surveillance of acute myocardial infarction in new users of saxagliptin: a population-based study
OBJECTIVE The cardiovascular safety of saxagliptin, a dipeptidyl-peptidase 4 inhibitor,
compared with other antihyperglycemic treatments is not well understood. We prospectively …
compared with other antihyperglycemic treatments is not well understood. We prospectively …
Real-world data analytics fit for regulatory decision-making
Healthcare database analyses (claims, electronic health records) have been identified by
various regulatory initiatives, including the 21st Century Cures Act and Prescription Drug …
various regulatory initiatives, including the 21st Century Cures Act and Prescription Drug …
A methodological review of the high-dimensional propensity score in comparative-effectiveness and safety-of-interventions research finds incomplete reporting …
GL Martin, C Petri, J Rozenberg, N Simon… - Journal of Clinical …, 2024 - Elsevier
Objectives The use of secondary databases has become popular for evaluating the
effectiveness and safety of interventions in real-life settings. However, the absence of …
effectiveness and safety of interventions in real-life settings. However, the absence of …