Converting nanotoxicity data to information using artificial intelligence and simulation

X Yan, T Yue, DA Winkler, Y Yin, H Zhu… - Chemical …, 2023 - ACS Publications
Decades of nanotoxicology research have generated extensive and diverse data sets.
However, data is not equal to information. The question is how to extract critical information …

Theoretical and computational investigations of nanoparticle–biomembrane interactions in cellular delivery

H Ding, Y Ma - Small, 2015 - Wiley Online Library
With the rapid development of nanotechnology, nanoparticles have been widely used in
many applications such as phototherapy, cell imaging, and drug/gene delivery. A better …

Long-term toxicity of surface-charged polystyrene nanoplastics to marine planktonic species Dunaliella tertiolecta and Artemia franciscana

E Bergami, S Pugnalini, ML Vannuccini, L Manfra… - Aquatic toxicology, 2017 - Elsevier
Plastic pollution has been globally recognized as a critical issue for marine ecosystems and
nanoplastics constitute one of the last unexplored areas to understand the magnitude of this …

The combined toxicity effect of nanoplastics and glyphosate on Microcystis aeruginosa growth

Q Zhang, Q Qu, T Lu, M Ke, Y Zhu, M Zhang… - Environmental …, 2018 - Elsevier
Waste plastics can be degraded to nanoplastics (NPs, diameter< 1 μm) by natural forces.
NPs not only directly affect aquatic organisms but also adsorb other pollutants, causing …

Cell membranes open “doors” for cationic nanoparticles/biomolecules: insights into uptake kinetics

J Lin, A Alexander-Katz - ACS nano, 2013 - ACS Publications
Cationic nanoparticles (NPs) and cell-penetrating peptides (CPPs) can enter cells in an
energy-independent fashion, esca** the traditional endocytosis route, which is known as …

Effect of particle diameter and surface composition on the spontaneous fusion of monolayer-protected gold nanoparticles with lipid bilayers

RC Van Lehn, PU Atukorale, RP Carney, YS Yang… - Nano …, 2013 - ACS Publications
Anionic, monolayer-protected gold nanoparticles (AuNPs) have been shown to
nondisruptively penetrate cellular membranes. Here, we show that a critical first step in the …

Nanoparticles meet cell membranes: probing nonspecific interactions using model membranes

KL Chen, GD Bothun - 2014 - ACS Publications
Nanotoxicity studies have shown that both carbon-based and inorganic engineered
nanoparticles can be toxic to microorganisms. While the pathways for cytotoxicity are diverse …

[HTML][HTML] Computational and experimental approaches for investigating nanoparticle-based drug delivery systems

M Ramezanpour, SSW Leung… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Most therapeutic agents suffer from poor solubility, rapid clearance from the blood stream, a
lack of targeting, and often poor translocation ability across cell membranes. Drug/gene …

Lipid tail protrusions mediate the insertion of nanoparticles into model cell membranes

RC Van Lehn, M Ricci, PHJ Silva, P Andreozzi… - Nature …, 2014 - nature.com
Recent work has demonstrated that charged gold nanoparticles (AuNPs) protected by an
amphiphilic organic monolayer can spontaneously insert into the core of lipid bilayers to …

Comparative ecotoxicity of polystyrene nanoparticles in natural seawater and reconstituted seawater using the rotifer Brachionus plicatilis

L Manfra, A Rotini, E Bergami, G Grassi, C Faleri… - Ecotoxicology and …, 2017 - Elsevier
The impact of nanoplastics using model polystyrene nanoparticles (PS NPs), anionic (PS-
COOH) and cationic (PS-NH 2), has been investigated on the marine rotifer Brachionus …