[HTML][HTML] The search for gene-gene interactions in genome-wide association studies: challenges in abundance of methods, practical considerations, and biological …
One of the primary goals in this era of precision medicine is to understand the biology of
human diseases and their treatment, such that each individual patient receives the best …
human diseases and their treatment, such that each individual patient receives the best …
Genome-wide association study as a powerful tool for dissecting competitive traits in legumes
Legumes are extremely valuable because of their high protein content and several other
nutritional components. The major challenge lies in maintaining the quantity and quality of …
nutritional components. The major challenge lies in maintaining the quantity and quality of …
Genetic architecture of abdominal aortic aneurysm in the million veteran program
Background: Abdominal aortic aneurysm (AAA) is an important cause of cardiovascular
mortality; however, its genetic determinants remain incompletely defined. In total, 10 …
mortality; however, its genetic determinants remain incompletely defined. In total, 10 …
PheWAS and beyond: the landscape of associations with medical diagnoses and clinical measures across 38,662 individuals from Geisinger
Most phenome-wide association studies (PheWASs) to date have used a small to moderate
number of SNPs for association with phenotypic data. We performed a large-scale single …
number of SNPs for association with phenotypic data. We performed a large-scale single …
A simulation study investigating power estimates in phenome-wide association studies
Background Phenome-wide association studies (PheWAS) are a high-throughput approach
to evaluate comprehensive associations between genetic variants and a wide range of …
to evaluate comprehensive associations between genetic variants and a wide range of …
Genomewide association study of platelet reactivity and cardiovascular response in patients treated with clopidogrel: a study by the international clopidogrel …
Antiplatelet response to clopidogrel shows wide variation, and poor response is correlated
with adverse clinical outcomes. CYP2C19 loss‐of‐function alleles play an important role in …
with adverse clinical outcomes. CYP2C19 loss‐of‐function alleles play an important role in …
OpenMendel: a cooperative programming project for statistical genetics
Statistical methods for genome-wide association studies (GWAS) continue to improve.
However, the increasing volume and variety of genetic and genomic data make …
However, the increasing volume and variety of genetic and genomic data make …
Methodology in phenome-wide association studies: a systematic review
Phenome-wide association study (PheWAS) has been increasingly used to identify novel
genetic associations across a wide spectrum of phenotypes. This systematic review aims to …
genetic associations across a wide spectrum of phenotypes. This systematic review aims to …
Large-scale genomic analyses reveal insights into pleiotropy across circulatory system diseases and nervous system disorders
Clinical and epidemiological studies have shown that circulatory system diseases and
nervous system disorders often co-occur in patients. However, genetic susceptibility factors …
nervous system disorders often co-occur in patients. However, genetic susceptibility factors …
Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy response
With the continued promise of immunotherapy for treating cancer, understanding how host
genetics contributes to the tumor immune microenvironment (TIME) is essential to tailoring …
genetics contributes to the tumor immune microenvironment (TIME) is essential to tailoring …