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TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases
Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …
Vascular mechanotransduction
This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …
Advances in TRP channel drug discovery: from target validation to clinical studies
Transient receptor potential (TRP) channels are multifunctional signalling molecules with
many roles in sensory perception and cellular physiology. Therefore, it is not surprising that …
many roles in sensory perception and cellular physiology. Therefore, it is not surprising that …
Recent advances in lipopolysaccharide recognition systems
Lipopolysaccharide (LPS), commonly known as endotoxin, is ubiquitous and the most-
studied pathogen-associated molecular pattern. A component of Gram-negative bacteria …
studied pathogen-associated molecular pattern. A component of Gram-negative bacteria …
Smooth muscle ion channels and regulation of vascular tone in resistance arteries and arterioles
Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …
Structure of human TRPV4 in complex with GTPase RhoA
Transient receptor potential (TRP) channel TRPV4 is a polymodal cellular sensor that
responds to moderate heat, cell swelling, shear stress, and small-molecule ligands. It is …
responds to moderate heat, cell swelling, shear stress, and small-molecule ligands. It is …
TRPV4: molecular conductor of a diverse orchestra
Transient receptor potential vanilloid type 4 (TRPV4) is a calcium-permeable nonselective
cation channel, originally described in 2000 by research teams led by Schultz (Nat Cell Biol …
cation channel, originally described in 2000 by research teams led by Schultz (Nat Cell Biol …
Piezo1 acts upstream of TRPV4 to induce pathological changes in endothelial cells due to shear stress
SM Swain, RA Liddle - Journal of Biological Chemistry, 2021 - jbc.org
The ion channels Piezo1 and TRPV4 have both, independently, been implicated in high
venous pressure–and fluid shear stress–induced vascular hyperpermeability in endothelial …
venous pressure–and fluid shear stress–induced vascular hyperpermeability in endothelial …
Visceral pain
Most of us live blissfully unaware of the orchestrated function that our internal organs
conduct. When this peace is interrupted, it is often by routine sensations of hunger and urge …
conduct. When this peace is interrupted, it is often by routine sensations of hunger and urge …
Transient receptor potential channels as drug targets: from the science of basic research to the art of medicine
The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …