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The immunology of sepsis
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host
response to an infection. This recently implemented definition does not capture the …
response to an infection. This recently implemented definition does not capture the …
Long-term outcomes after critical illness: recent insights
Intensive care survivors often experience post-intensive care sequelae, which are frequently
gathered together under the term “post-intensive care syndrome”(PICS). The consequences …
gathered together under the term “post-intensive care syndrome”(PICS). The consequences …
Sepsis and septic shock
Sepsis is a common condition that is associated with unacceptably high mortality and, for
many of those who survive, long-term morbidity. Increased awareness of the condition …
many of those who survive, long-term morbidity. Increased awareness of the condition …
Sepsis associated acute kidney injury
Sepsis is defined as organ dysfunction resulting from the host's deleterious response to
infection. One of the most common organs affected is the kidneys, resulting in sepsis …
infection. One of the most common organs affected is the kidneys, resulting in sepsis …
Enhancing recovery from sepsis: a review
Importance Survival from sepsis has improved in recent years, resulting in an increasing
number of patients who have survived sepsis treatment. Current sepsis guidelines do not …
number of patients who have survived sepsis treatment. Current sepsis guidelines do not …
Sepsis therapies: learning from 30 years of failure of translational research to propose new leads
Sepsis has been identified by the World Health Organization (WHO) as a global health
priority. There has been a tremendous effort to decipher underlying mechanisms …
priority. There has been a tremendous effort to decipher underlying mechanisms …
The immune system's role in sepsis progression, resolution, and long‐term outcome
Sepsis occurs when an infection exceeds local tissue containment and induces a series of
dysregulated physiologic responses that result in organ dysfunction. A subset of patients …
dysregulated physiologic responses that result in organ dysfunction. A subset of patients …
Mortality of patients with sepsis administered piperacillin-tazobactam vs cefepime
Importance Experimental and observational studies have suggested that empirical treatment
for bacterial sepsis with antianaerobic antibiotics (eg, piperacillin-tazobactam) is associated …
for bacterial sepsis with antianaerobic antibiotics (eg, piperacillin-tazobactam) is associated …
Cerebral dysfunctions caused by sepsis during ageing
Systemic inflammation elicited by sepsis can induce an acute cerebral dysfunction known as
sepsis-associated encephalopathy (SAE). Recent evidence suggests that SAE is common …
sepsis-associated encephalopathy (SAE). Recent evidence suggests that SAE is common …
Septic cardiomyopathy
Objectives: To describe, with an emphasis on clinical applications, what is known about the
pathophysiology, management, and implications of septic cardiomyopathy in the adult ICU …
pathophysiology, management, and implications of septic cardiomyopathy in the adult ICU …