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Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution
Our ancestors acquired morphological, cognitive and metabolic modifications that enabled
humans to colonize diverse habitats, develop extraordinary technologies and reshape the …
humans to colonize diverse habitats, develop extraordinary technologies and reshape the …
History, discovery, and classification of lncRNAs
Abstract The RNA World Hypothesis suggests that prebiotic life revolved around RNA
instead of DNA and proteins. Although modern cells have changed significantly in 4 billion …
instead of DNA and proteins. Although modern cells have changed significantly in 4 billion …
Molecular and cellular evolution of the primate dorsolateral prefrontal cortex
The granular dorsolateral prefrontal cortex (dlPFC) is an evolutionary specialization of
primates that is centrally involved in cognition. We assessed more than 600,000 single …
primates that is centrally involved in cognition. We assessed more than 600,000 single …
[HTML][HTML] Rewiring of human neurodevelopmental gene regulatory programs by human accelerated regions
Human accelerated regions (HARs) are the fastest-evolving regions of the human genome,
and many are hypothesized to function as regulatory elements that drive human-specific …
and many are hypothesized to function as regulatory elements that drive human-specific …
Three-dimensional genome rewiring in loci with human accelerated regions
Human accelerated regions (HARs) are conserved genomic loci that evolved at an
accelerated rate in the human lineage and may underlie human-specific traits. We …
accelerated rate in the human lineage and may underlie human-specific traits. We …
Supervised machine learning for population genetics: a new paradigm
As population genomic datasets grow in size, researchers are faced with the daunting task
of making sense of a flood of information. To keep pace with this explosion of data …
of making sense of a flood of information. To keep pace with this explosion of data …
Evolution of the human nervous system function, structure, and development
The nervous system—in particular, the brain and its cognitive abilities—is among humans'
most distinctive and impressive attributes. How the nervous system has changed in the …
most distinctive and impressive attributes. How the nervous system has changed in the …
Evolution of central neural circuits: state of the art and perspectives
The wide variety of animal behaviours that can be observed today arose through the
evolution of their underlying neural circuits. Advances in understanding the mechanisms …
evolution of their underlying neural circuits. Advances in understanding the mechanisms …
Adaptive sequence divergence forged new neurodevelopmental enhancers in humans
Searches for the genetic underpinnings of uniquely human traits have focused on human-
specific divergence in conserved genomic regions, which reflects adaptive modifications of …
specific divergence in conserved genomic regions, which reflects adaptive modifications of …
Chromatin accessibility dynamics in a model of human forebrain development
INTRODUCTION The cerebral cortex is responsible for higher-order functions in the nervous
system and has undergone substantial expansion in size in primates. The development of …
system and has undergone substantial expansion in size in primates. The development of …