Stem cells are characterized by their ability to self-renew and differentiate into many different
cell types. Research has focused primarily on how these processes are regulated at a …

Although human embryonic stem cells (hESCs) were first derived almost 20 years ago, it
was only recently acknowledged that they share closer molecular and functional identity to …

Execution of pluripotency requires progression from the naïve status represented by mouse
embryonic stem cells (ESCs) to a state capacitated for lineage specification. This transition is …

Abstract Tankyrase 1 (TNKS1; PARP-5a) and Tankyrase 2 (TNKS2; PARP-5b) are poly-ADP-
ribosyl-polymerase (PARP)-domain-containing proteins that regulate the activities of a wide …

Pluripotent character is described as the potency of cells to differentiate into all three germ
layers. The best example to reinstate the term lies in the context of embryonic stem cells …

In this paper, we summarize the current knowledge of the role of proline metabolism in the
control of the identity of Embryonic Stem Cells (ESCs). An imbalance in proline metabolism …

Cerebral cortical development is controlled by key transcription factors that specify the
neuronal identities in the different layers. The mechanisms controlling their expression in …

DNA, RNA, and the proteins are the major players in the flow of genetic information. Out of
these, RNA is the most versatile biomolecule as it exists in multiple forms and each form …

The mammalian neocortex is a complex arrangement of neurons organized by a rigorous
stratification into six layers (I-VI) following an inside-out mechanism that gives each of these …

Accurately modeling human-related neuronal phenomena remains at the forefront of
neuroscience. This thesis utilizes already-established in vitro models of mouse embryonic …