Rapamycin, a macrocyclic lactone, is a highly specific inhibitor of the serine/threonine
protein kinase target of rapamycin (TOR). Although it is clear that TOR controls initiation of …

Forkhead proteins, and FoxO1 in particular, play a significant role in regulating whole body
energy metabolism. Glucose homeostasis is achieved by adjusting endogenous glucose …

The mammalian target of rapamycin (mTOR) integrates nutrient and mitogen signals to
regulate cell growth (increased cell mass and cell size) and cell division. The …

Non‐Technical Summary Chronic mechanical loading (CML) of skeletal muscle induces
growth and this effect can be blocked by the drug rapamycin. Rapamycin is considered to be …

Adipocyte differentiation is a developmental process that is critical for metabolic
homeostasis and nutrient signaling. The mammalian target of rapamycin (mTOR) mediates …

Mammalian target of rapamycin (mTOR) is a key regulator of cell growth that associates with
raptor and rictor to form the mTOR complex 1 (mTORC1) and mTORC2, respectively. Raptor …

Muscle differentiation is a crucial process controlling muscle development and homeostasis.
Mitochondrial reactive oxygen species (mtROS) rapidly increase and function as critical cell …

The mammalian target of rapamycin (mTOR), an atypical serine/threonine kinase, plays a
central role in the regulation of cell proliferation, growth, differentiation, migration and …

Vitamin D deficiency is linked to a range of muscle disorders including myalgia, muscle
weakness, and falls. Humans with severe vitamin D deficiency and mice with transgenic …

Protein kinases are known primarily for their ability to phosphorylate protein substrates,
which constitutes an essential biological process. Recently, compelling evidence has …