Relaxed targeting rules help PIWI proteins silence transposons
In eukaryotes, small RNA guides, such as small interfering RNAs and microRNAs, direct
AGO-clade Argonaute proteins to regulate gene expression and defend the genome against …
AGO-clade Argonaute proteins to regulate gene expression and defend the genome against …
A single mechanism of biogenesis, initiated and directed by PIWI proteins, explains piRNA production in most animals
In animals, PIWI-interacting RNAs (piRNAs) guide PIWI proteins to silence transposons and
regulate gene expression. The mechanisms for making piRNAs have been proposed to …
regulate gene expression. The mechanisms for making piRNAs have been proposed to …
A maternally programmed intergenerational mechanism enables male offspring to make piRNAs from Y-linked precursor RNAs in Drosophila
In animals, PIWI-interacting RNAs (piRNAs) direct PIWI proteins to silence complementary
targets such as transposons. In Drosophila and other species with a maternally specified …
targets such as transposons. In Drosophila and other species with a maternally specified …
Terminal modification, sequence, length, and PIWI-protein identity determine piRNA stability
In animals, PIWI-interacting RNAs (piRNAs) silence transposons, fight viral infections, and
regulate gene expression. piRNA biogenesis concludes with 3′ terminal trimming and 2 …
regulate gene expression. piRNA biogenesis concludes with 3′ terminal trimming and 2 …
The genome of the Hi5 germ cell line from Trichoplusia ni, an agricultural pest and novel model for small RNA biology
We report a draft assembly of the genome of Hi5 cells from the lepidopteran insect pest,
Trichoplusia ni, assigning 90.6% of bases to one of 28 chromosomes and predicting 14,037 …
Trichoplusia ni, assigning 90.6% of bases to one of 28 chromosomes and predicting 14,037 …
The developmentally timed decay of an essential microRNA family is seed-sequence dependent
MicroRNA (miRNA) abundance is tightly controlled by regulation of biogenesis and decay.
Here, we show that the mir-35 miRNA family undergoes selective decay at the transition …
Here, we show that the mir-35 miRNA family undergoes selective decay at the transition …
Long noncoding miRNA gene represses wheat β-diketone waxes
The cuticle of terrestrial plants functions as a protective barrier against many biotic and
abiotic stresses. In wheat and other Triticeae, β-diketone waxes are major components of …
abiotic stresses. In wheat and other Triticeae, β-diketone waxes are major components of …
Effective and accurate gene silencing by a recombinant AAV-compatible microRNA scaffold
Short hairpin RNAs that are delivered by recombinant adeno-associated virus (rAAV) have
the potential to elicit long-term RNAi therapy for human disease. However, the discovery that …
the potential to elicit long-term RNAi therapy for human disease. However, the discovery that …
Molecular basis for cytoplasmic RNA surveillance by uridylation‐triggered decay in Drosophila
MM Reimão‐Pinto, RA Manzenreither… - The EMBO …, 2016 - embopress.org
The posttranscriptional addition of nucleotides to the 3′ end of RNA regulates the
maturation, function, and stability of RNA species in all domains of life. Here, we show that in …
maturation, function, and stability of RNA species in all domains of life. Here, we show that in …
Two modes of targeting transposable elements by piRNA pathway in human testis
I Gainetdinov, Y Skvortsova, S Kondratieva, S Funikov… - Rna, 2017 - rnajournal.cshlp.org
PIWI proteins and their partner small RNAs, termed piRNAs, are known to control
transposable elements (TEs) in the germline. Here, we provide evidence that in humans this …
transposable elements (TEs) in the germline. Here, we provide evidence that in humans this …