Exciting recent developments suggest that phase transitions represent an important and
ubiquitous mechanism underlying intracellular organization. We describe key experimental …

The organization of microtubule networks is crucial for controlling chromosome segregation
during cell division, for positioning and transport of different organelles, and for cell polarity …

Centrosomes are non-membrane-bound compartments that nucleate microtubule arrays.
They consist of nanometer-scale centrioles surrounded by a micron-scale, dynamic …

Summary In flies, Centrosomin (Cnn) forms a phosphorylation-dependent scaffold that
recruits proteins to the mitotic centrosome, but how Cnn assembles into a scaffold is unclear …

Mitotic cell divisions increase cell number while faithfully distributing the replicated genome
at each division. The Caenorhabditis elegans embryo is a powerful model for eukaryotic cell …

The centriole is a multifunctional structure that organizes centrosomes and cilia and is
important for cell signaling, cell cycle progression, polarity, and motility. Defects in centriole …

Centrosomes were first described by Edouard Van Beneden and named and linked to
chromosome segregation by Theodor Boveri around 1870. In the 1960–1980s, electron …

The outermost layer of centrosomes, called pericentriolar material (PCM), organizes
microtubules for mitotic spindle assembly. The molecular interactions that enable PCM to …

There is currently intense interest in the idea that many membraneless organelles might
assemble through phase separation of their constituent molecules into biomolecular' …

The centrosome acts as a microtubule organizing center (MTOC), orchestrating microtubules
into the mitotic spindle through its pericentriolar material (PCM). This activity is biphasic …