The ability to design efficient enzymes from scratch would have a profound effect on
chemistry, biotechnology and medicine. Rapid progress in protein engineering over the past …

Biocatalysis has become an important aspect of modern organic synthesis, both in
academia and across the chemical and pharmaceutical industries. Its success has been …

In recent years, powerful genetic code reprogramming methods have emerged that allow
new functional components to be embedded into proteins as noncanonical amino acid …

Light is a nearly ideal stimulus for molecular systems. It delivers information encoded in the
form of wavelengths and their intensities with high precision in space and time. Light is a …

Low molecular weight synthetic peptides have been demonstrated to be effective catalysts
for an increasingly wide array of asymmetric transformations. In many cases, these peptide …

One of the hallmark advances in our understanding of metalloprotein function is showcased
in our ability to design new, non-native, catalytically active protein scaffolds. This review …

Recent developments in computational chemistry and biology have come together in the
“inside‐out” approach to enzyme engineering. Proteins have been designed to catalyze …

The two main strategies for enzyme engineering, directed evolution and rational design,
have found widespread applications in improving the intrinsic activities of proteins. Although …

Ferroptosis is an iron-dependent form of cell death driven by oxidation of polyunsaturated
fatty acid (PUFA) phospholipids. Large-scale genetic screens have uncovered a specialized …

Enzymes achieve high catalytic activity with their elaborate arrangements of amino acid
residues in confined optimized spaces. Nevertheless, when exposed to complicated …