Absence seizures in children and teenagers are generally considered relatively benign
because of their non-convulsive nature and the large incidence of remittance in early …

The brain is in a constant state of dynamic change, for example switching between cognitive
and behavioural tasks, and between wakefulness and sleep. The brains of people with …

Whether functional magnetic resonance imaging (fMRI) allows the identification of neural
drivers remains an open question of particular importance to refine physiological and …

Typical absence has long been considered as the prototypic form of generalized
nonconvulsive epileptic seizures. Recent investigations in patients and animal models …

Cenobamate is a novel antiepileptic drug under investigation for use in patients with focal
(partial-onset) seizures. To understand its potential molecular mechanism of action, the …

GABAA receptors mediate most of the fast inhibitory transmission in the CNS. They form
heteromeric complexes assembled from a large family of subunit genes. The existence of …

Central thalamus plays a critical role in forebrain arousal and organized behavior. However,
network-level mechanisms that link its activity to brain state remain enigmatic. Here, we …

A great number of clinical observations show a relationship between epilepsy and
depression. Idiopathic generalized epilepsy, including absence epilepsy, has a genetic …

Thalamic relay neurons have well-characterized dual firing modes: bursting and tonic
spiking. Studies in brain slices have led to a model in which rhythmic synchronized spiking …

Parvalbumin is a calcium-binding protein present in inhibitory interneurons that play an
essential role in regulating many physiological processes, such as intracellular signaling …