APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer's disease pathology and brain diseases
R Fernández-Calle, SC Konings… - Molecular …, 2022 - Springer
ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …
TREM2 dependent and independent functions of microglia in Alzheimer's disease
Microglia are central players in brain innate immunity and have been the subject of
extensive research in Alzheimer's disease (AD). In this review, we aim to summarize the …
extensive research in Alzheimer's disease (AD). In this review, we aim to summarize the …
[HTML][HTML] Integrated multimodal cell atlas of Alzheimer's disease
Alzheimer's disease (AD) is the leading cause of dementia in older adults. Although AD
progression is characterized by stereotyped accumulation of proteinopathies, the affected …
progression is characterized by stereotyped accumulation of proteinopathies, the affected …
Associations between handgrip strength and dementia risk, cognition, and neuroimaging outcomes in the UK Biobank cohort study
Importance The associations between muscle strength and cognitive outcomes have
sparked interest in interventions that increase muscle strength for prevention of dementia …
sparked interest in interventions that increase muscle strength for prevention of dementia …
Sex and gender differences in caregiving burden experienced by family caregivers of persons with dementia: A systematic review
Objectives Much is known about the demands of caregiving for persons with dementia
(PWD) and its effects on family caregivers, however sex and gender aspects have received …
(PWD) and its effects on family caregivers, however sex and gender aspects have received …
Thyroid hormone: sex-dependent role in nervous system regulation and disease
Thyroid hormone (TH) regulates many functions including metabolism, cell differentiation,
and nervous system development. Alteration of thyroid hormone level in the body can lead …
and nervous system development. Alteration of thyroid hormone level in the body can lead …
Olfactory dysfunction, headache, and mental clouding in adults with long-COVID-19: what is the link between cognition and olfaction? A cross-sectional study
Smell alteration and cognitive impairment are common features of the Long-COVID
Syndrome. Mental clouding, often described as brain fog, might affect smell by altering …
Syndrome. Mental clouding, often described as brain fog, might affect smell by altering …
Adiponectin and cognitive decline
Adiponectin (ADPN) is a plasma protein secreted by adipose tissue showing pleiotropic
effects with anti-diabetic, anti-atherogenic, and anti-inflammatory properties. Initially, it was …
effects with anti-diabetic, anti-atherogenic, and anti-inflammatory properties. Initially, it was …
Aging triggers an upregulation of a multitude of cytokines in the male and especially the female rodent hippocampus but more discrete changes in other brain regions
L Porcher, S Bruckmeier, SD Burbano… - Journal of …, 2021 - Springer
Background Despite widespread acceptance that neuroinflammation contributes to age-
related cognitive decline, studies comparing protein expression of cytokines in the young …
related cognitive decline, studies comparing protein expression of cytokines in the young …
[HTML][HTML] Advancing personalized medicine in neurodegenerative diseases: The role of epigenetics and pharmacoepigenomics in pharmacotherapy
About 80% of brain disorders have a genetic basis. The pathogenesis of most
neurodegenerative diseases is associated with a myriad of genetic defects, epigenetic …
neurodegenerative diseases is associated with a myriad of genetic defects, epigenetic …