In patients with Parkinson's disease and in animal models of this disorder, neurons in the
basal ganglia and related regions in thalamus and cortex show changes that can be …

Movement abnormalities of Parkinson's disease (PD) arise from disordered neural activity in
multiple interconnected brain structures. The planning and execution of movement requires …

The motor cortex controls skilled arm movement by sending temporal patterns of activity to
lower motor centres. Local cortical dynamics are thought to shape these patterns throughout …

Behavior is readily classified into patterns of movements with inferred common goals—
actions. Goals may be discrete; movements are continuous. Through the careful study of …

With our eyes closed, we can track a limb's moment-to-moment location in space. If this
capacity relied solely on sensory feedback from the limb, we would always be a step behind …

The thalamus is the hub through which neural signals are transmitted from the basal ganglia
and cerebellum to the neocortex. However, thalamocortical axonal activity during motor …

The primary motor cortex, a dynamic center for overall motion control and decision making,
undergoes significant alterations upon neural stimulation. Over the last few decades, data …

Motor thalamus (Mthal) comprises the ventral anterior, ventral lateral, and ventral medial
thalamic nuclei in rodents. This subcortical hub receives input from the basal ganglia (BG) …

Degeneration of midbrain dopaminergic (DA) neurons alters the connectivity and
functionality of the basal ganglia-thalamocortical circuits in Parkinson's disease (PD) …

Background Single pellet reaching is an established task for studying fine motor control in
which rats reach for, grasp, and eat food pellets in a stereotyped sequence. Most …