Aging is characterized by the accumulation of damage and other deleterious changes,
leading to the loss of functionality and fitness. Age-related changes occur at most levels of …

Cellular stress is an intrinsic part of cell physiology that underlines cell survival or death. The
ability of mammalian cells to regulate global protein synthesis (aka translational control) …

Cells have developed different mechanisms to respond to stress, including the formation of
cytoplasmic foci known as stress granules (SGs). SGs are dynamic and formed as a result of …

Whether post-transcriptional regulation of gene expression controls differentiation of stem
cells for tissue renewal remains unknown. Quiescent stem cells exhibit a low level of protein …

Internal ribosome entry sites (IRESs) can be found in the mRNA of many viruses as well as
in cellular genes involved in the stress response, cell cycle, and apoptosis. IRES-mediated …

Abstract The development of Ribosome Profiling (RiboSeq) has revolutionized functional
genomics. RiboSeq is based on capturing and sequencing of the mRNA fragments enclosed …

Eukaryotic ribosome and cap-dependent translation are attractive targets in the antitumor,
antiviral, anti-inflammatory, and antiparasitic therapies. Currently, a broad array of small …

Translation is critical for development as transcription in the oocyte and early embryo is
silenced. To illustrate the translational changes during meiosis and consecutive two mitoses …

Gap Junction (GJ) channels, including the most common Connexin 43 (Cx43), have
fundamental roles in excitable tissues by facilitating rapid transmission of action potentials …

Small open reading frames (sORFs) are an often overlooked feature of plant genomes.
Initially found in plant viral RNAs and considered an interesting curiosity, an increasing …