DNAzyme-based biosensors: Immobilization strategies, applications, and future prospective

S Khan, B Burciu, CDM Filipe, Y Li, K Dellinger… - Acs Nano, 2021 - ACS Publications
Since their discovery almost three decades ago, DNAzymes have been used extensively in
biosensing. Depending on the type of DNAzyme being used, these functional …

Challenges and opportunities for develo** electrochemical biosensors with commercialization potential in the point-of-care diagnostics market

AA Akhlaghi, H Kaur, BR Adhikari… - ECS Sensors Plus, 2024 - iopscience.iop.org
There is a plethora of electrochemical biosensors developed for ultrasensitive detection of
clinically relevant biomarkers. However, many of these systems lose their performance in …

Cascade signal amplifying strategy for ultrasensitive detection of tumor biomarker by DNAzyme cleaving mediated HCR

H Chen, J Song, Y Li, D Deng, Y Song, X Zhu… - Sensors and Actuators B …, 2024 - Elsevier
Tumor biomarkers are a kind of important biomolecules for aiding cancer diagnosis and
assessing tumor efficacy, among which alpha-fetoprotein (AFP) is a crucial tumor biomarker …

Functional nucleic acids for pathogenic bacteria detection

D Chang, S Zakaria, S Esmaeili Samani… - Accounts of chemical …, 2021 - ACS Publications
Conspectus Pathogens have long presented a significant threat to human lives, and hence
the rapid detection of infectious pathogens is vital for improving human health. Current …

Electrochemical DNAzyme-based biosensors for disease diagnosis

R Pandey, Y Lu, EM McConnell, E Osman… - Biosensors and …, 2023 - Elsevier
DNAzyme-based electrochemical biosensors provide exceptional analytical sensitivity and
high target recognition specificity for disease diagnosis. This review provides a critical …

DNAzyme-immobilizing microgel magnetic beads enable rapid, specific, culture-free, and wash-free electrochemical quantification of bacteria in untreated urine

R Pandey, Y Lu, E Osman, S Saxena, Z Zhang… - ACS …, 2022 - ACS Publications
Rapid, ultrasensitive, and specific detection and identification of bacteria in unprocessed
clinical specimens is critically needed to enable point-of-care diagnosis of infectious …

DNAzyme‐Functionalized Nanomaterials: Recent Preparation, Current Applications, and Future Challenges

J Jouha, H **ong - Small, 2021 - Wiley Online Library
DNAzyme–nanomaterial bioconjugates are a popular hybrid and have received major
attention for diverse biomedical applications, such as bioimaging, biosensor development …

DNAzyme-based cascade signal amplification strategy for highly sensitive detection of lead ions in the environment

J Xu, M Liu, W Zhao, S Wang, M Gui, H Li… - Journal of Hazardous …, 2022 - Elsevier
Lead ions are one of many common environmental pollutants, that can cause posing a
serious threat to people's health, thus, their efficient and sensitive detection is important. We …

Making target sites in large structured RNAs accessible to RNA-cleaving DNAzymes through hybridization with synthetic DNA oligonucleotides

C Nurmi, J Gu, A Mathai, JD Brennan… - Nucleic Acids …, 2024 - academic.oup.com
The 10–23 DNAzyme is one of the most active DNA-based enzymes, and in theory, can be
designed to target any purine-pyrimidine junction within an RNA sequence for cleavage …

Ratiometric detection of lithium ions in serum and living cells using DNAzyme-assisted hybridization chain reaction

J Wang, Z Feng, J Zhan, Y Shi, J Zhang - Sensors and Actuators B …, 2024 - Elsevier
Lithium, a first-line mood stabilizer for bipolar disorder (BD), presents challenges due to its
narrow therapeutic window (0.6–1.2 mM) and potential side effects in overdose. Hence, it is …