Gene therapy holds great promise for treating a multitude of inherited and acquired diseases
by delivering functional genes, comprising DNA or RNA, into targeted cells or tissues to elicit …

Self-assembled organic nanotubes made of single or multiple molecular components can be
classified into soft-matter nanotubes (SMNTs) by contrast with hard-matter nanotubes, such …

The construction of complex polymer architectures with well-defined topology, composition
and functionality has been extensively explored as the molecular basis for the development …

Nonviral gene therapy holds great promise but has not delivered treatments for clinical
application to date. Lack of safe and efficient gene delivery vectors is the major hurdle …

Cytosolic delivery is the major challenge that limits the clinical translation of siRNA-based
therapeutics. Although thousands of polymers have been developed for siRNA delivery, the …

Nanomedicine is a discipline that applies nanoscience and nanotechnology principles to the
prevention, diagnosis, and treatment of human diseases. Self-assembly of molecular …

Current medical adhesives based on cyanoacrylates typically exhibit cellular toxicity. In
contrast, fibrin adhesives are non-toxic but have poor adhesive properties. To overcome …

Current therapies for most neurodegenerative disorders are only symptomatic in nature and
do not change the course of the disease. Gene therapy plays an important role in disease …

Nanocarriers have attracted broad attention in cancer therapy because of their ability to
carry drugs preferentially into cancer tissue, but their application is still limited due to the …

Highlights•Minor modifications to polymer structure determine transfection
properties.•Efficient gene delivery requires timely release of DNA.•Serum stability is …