Currently, there are very few guidelines linking the results of pharmacogenetic tests to
specific therapeutic recommendations. Therefore, the Royal Dutch Association for the …

Warfarin is a widely used anticoagulant with a narrow therapeutic index and large
interpatient variability in the dose required to achieve target anticoagulation. Common …

Komisję ESC ds. Wytycznych Postępowania nadzoruje i koordynuje przygotowywanie
nowych wytycznych i stanowisk przez grupy robocze i inne grupy ekspertów. Komitet jest …

Background The level of anticoagulation in response to a fixed-dose regimen of warfarin is
difficult to predict during the initiation of therapy. We prospectively compared the effect of …

The synthesis of coumarins through Knoevenagel condensation is one of the most important
processes in synthetic organic chemistry and medicinal chemistry. Compounds including a …

Summary Background VKORC1 and CYP2C9 are important contributors to warfarin dose
variability, but explain less variability for individuals of African descent than for those of …

Se recomienda a los profesionales de la salud que tengan en consideración la presente
guía de la ESC/EACTS en la toma de decisiones clínicas en su ejercicio diario, así como en …

Background Observational evidence suggests that the use of a genotype-guided dosing
algorithm may increase the effectiveness and safety of acenocoumarol and phenprocoumon …

Coumarin derivatives, such as warfarin, acenocoumarol and phenprocoumon are frequently
prescribed oral anticoagulants to treat and prevent thromboembolism. Because there is a …

Background The use of pharmacogenomic testing in the clinical setting has the potential to
improve the safety and effectiveness of drug therapy, yet studies have revealed that …