Despite its position as the first-line drug for treatment of type 2 diabetes mellitus, the
mechanisms underlying the plasma glucose level-lowering effects of metformin (1, 1 …

Metformin is currently the first-line drug treatment for type 2 diabetes. Besides its glucose-
lowering effect, there is interest in actions of the drug of potential relevance to cardiovascular …

Considerable efforts have been made since the 1950s to better understand the cellular and
molecular mechanisms of action of metformin, a potent antihyperglycaemic agent now …

Metformin has been the mainstay of therapy for diabetes mellitus for many years; however,
the mechanistic aspects of metformin action remained ill-defined. Recent advances revealed …

Glucose homeostasis is tightly regulated to meet the energy requirements of the vital organs
and maintain an individual's health. The liver has a major role in the control of glucose …

Hepatic gluconeogenesis, de novo glucose synthesis from available precursors, plays a
crucial role in maintaining glucose homeostasis to meet energy demands during prolonged …

Type 2 diabetes mellitus is characterized by the dysregulation of glucose homeostasis,
resulting in hyperglycaemia. Although current diabetes treatments have exhibited some …

Metformin, a frontline treatment for type II diabetes mellitus, decreases production of the pro-
form of the inflammatory cytokine IL-1β in response to LPS in macrophages. We found that it …

For many years, bile acids were thought to only function as detergents which solubilize fats
and facilitate the uptake of fat-soluble vitamins in the intestine. Many early observations; …

Liver plays a major role in maintaining glucose homeostasis in mammals. Under fasting
conditions, hepatic glucose production is critical as a source of fuel to maintain the basic …