Metformin has been designated as one of the most crucial first-line therapeutic agents in the
management of type 2 diabetes mellitus. Primarily being an antihyperglycemic agent …

Sertoli cells are somatic cells present in seminiferous tubules which have essential roles in
regulating spermatogenesis. Considering that each Sertoli cell is able to support a limited …

Cancer continues to pose a significant global health challenge, as evidenced by the
increasing incidence rates and high mortality rates, despite the advancements made in …

BACKGROUND Epidemiologic studies suggest that metformin has antitumor effects.
Laboratory studies indicate metformin impacts cancer stem-like cells (CSCs). As part of a …

Metformin is the most widely used antidiabetic drug in the world, and there is increasing
evidence of a potential efficacy of this agent as an anticancer drug. First, epidemiological …

Epidemiological studies suggest a positive association between obesity and type 2 diabetes
mellitus (T2D) with the risk of cancer and cancer-related mortality. Insulin resistance …

Adenosine monophosphate-activated protein kinase (AMPK) acts as a major sensor of
cellular energy status in cancers and is critically involved in cell sensitivity to anticancer …

Ovarian cancer is the most lethal gynecologic cancer in women. Its high mortality rate (68%)
reflects the fact that 75% of patients have extensive (> stage III) disease at diagnosis and …

Metformin is the most widely used antidiabetic drug because of its proven efficacy and
limited secondary effects. Interestingly, recent studies have reported that metformin can …

Ovarian cancer (OvCa) is the fifth most common cause of death from all cancers among
women in United Sates and the leading cause of death from gynecological malignancies …