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Efficacy and comparative effectiveness of atypical antipsychotic medications for off-label uses in adults: a systematic review and meta-analysis
Context Atypical antipsychotic medications are commonly used for off-label conditions such
as agitation in dementia, anxiety, and obsessive-compulsive disorder. Objective To perform …
as agitation in dementia, anxiety, and obsessive-compulsive disorder. Objective To perform …
Gene–environment interactions in psychiatry: joining forces with neuroscience
Gene–environment interaction research in psychiatry is new, and is a natural ally of
neuroscience. Mental disorders have known environmental causes, but there is …
neuroscience. Mental disorders have known environmental causes, but there is …
Neurobiologic processes in drug reward and addiction
Neurophysiologic processes underlie the uncontrolled, compulsive behaviors defining the
addicted state. These “hard-wired” changes in the brain are considered critical for the …
addicted state. These “hard-wired” changes in the brain are considered critical for the …
Relapse prevention for addictive behaviors
Abstract The Relapse Prevention (RP) model has been a mainstay of addictions theory and
treatment since its introduction three decades ago. This paper provides an overview and …
treatment since its introduction three decades ago. This paper provides an overview and …
Genetics of dopamine receptors and drug addiction: a comprehensive review
Drug dependence is a chronic, relapsing disorder in which compulsive drug-seeking and
drug-taking behaviours persist despite serious negative consequences. Addictive …
drug-taking behaviours persist despite serious negative consequences. Addictive …
Exposure to the taste of alcohol elicits activation of the mesocorticolimbic neurocircuitry
A growing number of imaging studies suggest that alcohol cues, mainly visual, elicit
activation in mesocorticolimbic structures. Such findings are consistent with the growing …
activation in mesocorticolimbic structures. Such findings are consistent with the growing …
Examining impulsivity as an endophenotype using a behavioral approach: a DRD2 TaqI A and DRD4 48-bp VNTR association study
Background Research on the genetic basis for impulsivity has revealed an array of
ambiguous findings. This may be a result of limitations to self-report assessments of …
ambiguous findings. This may be a result of limitations to self-report assessments of …
The role of the orbitofrontal cortex in alcohol use, abuse, and dependence
One of the major functions of the orbitofrontal cortex (OFC) is to promote flexible motivated
behavior. It is no surprise, therefore, that recent work has demonstrated a prominent impact …
behavior. It is no surprise, therefore, that recent work has demonstrated a prominent impact …
Alcohol use disorder and antisocial and borderline personality disorders
Alcohol use disorder (AUD) frequently co-occurs with other psychiatric disorders, including
personality disorders, which are pervasive, persistent, and impairing. Personality disorders …
personality disorders, which are pervasive, persistent, and impairing. Personality disorders …
Rodent versions of the iowa gambling task: opportunities and challenges for the understanding of decision-making
Impaired decision-making is a core problem in several psychiatric disorders including
attention-deficit/hyperactivity disorder, schizophrenia, obsessive–compulsive disorder …
attention-deficit/hyperactivity disorder, schizophrenia, obsessive–compulsive disorder …