[HTML][HTML] Metabolic perturbations in pregnant rats exposed to low-dose perfluorooctanesulfonic acid: An integrated multi-omics analysis

G Yu, J Wang, Y Liu, T Luo, X Meng, R Zhang… - Environment …, 2023 - Elsevier
Emerging epidemiological evidence has linked per-and polyfluoroalkyl substances (PFAS)
exposure could be linked to the disturbance of gestational glucolipid metabolism, but the …

Legacy and Emerging Per- and Polyfluoroalkyl Substances Surveillance in Bufo gargarizans from Inlet Watersheds of Chaohu Lake, China: Tissue Distribution and …

Y Shu, Q Wang, P Hong, Y Ruan, H Lin… - Environmental …, 2023 - ACS Publications
Amphibians are sensitive biomonitors of environmental pollutants but reports regarding per-
and polyfluoroalkyl substances (PFAS), a class of synthetic organofluorine substances, are …

Domestic dogs and horses as sentinels of per-and polyfluoroalkyl substance exposure and associated health biomarkers in Gray's Creek North Carolina

KD Rock, ME Polera, TC Guillette… - … science & technology, 2023 - ACS Publications
Central North Carolina (NC) is highly contaminated with per-and polyfluoroalkyl substances
(PFAS), in part due to local fluorochemical production. Little is known about the exposure …

Gestational GenX and PFOA exposures induce hepatotoxicity, metabolic pathway, and microbiome shifts in weanling mice

QY Zhang, LL Xu, MT Zhong, YK Chen, MQ Lai… - Science of the Total …, 2024 - Elsevier
Abstract Ammonium perfluoro (2-methyl-3-oxahexanoate)(GenX), a replacement for
perfluorooctanoic acid (PFOA), has been detected in multiple environmental media and …

Insights into Toxicological Mechanisms of Per-/polyfluoroalkyl Substances by Using Omics-centered Approaches

X Zhou, F Hu, Y Chen, K **e, WJ Hong, M Li… - Environmental …, 2025 - Elsevier
The extensive presence of per-/polyfluoroalkyl substances (PFASs) in the environment and
their adverse effects on organisms have garnered increasing concern. With the shift of …

In utero exposures to perfluoroalkyl substances and the human fetal liver metabolome in Scotland: a cross-sectional study

T Hyötyläinen, A McGlinchey, S Salihovic… - The Lancet Planetary …, 2024 - thelancet.com
Background Perfluoroalkyl and polyfluoroalkyl substances are classed as endocrine
disrupting compounds but continue to be used in many products such as firefighting foams …

Transcriptomics integrated with metabolomics reveals perfluorobutane sulfonate (PFBS) exposure effect during pregnancy and lactation on lipid metabolism in rat …

X Meng, G Yu, T Luo, R Zhang, J Zhang, Y Liu - Chemosphere, 2023 - Elsevier
Emerging epidemiological evidence indicates potential associations between gestational
perfluorobutane sulfonate (PFBS) exposure and adverse metabolic outcomes in offspring …

Maternal and Neonatal Effects of Maternal Oral Exposure to Perfluoro-2-methoxyacetic Acid (PFMOAA) during Pregnancy and Early Lactation in the Sprague–Dawley …

JM Conley, CS Lambright, N Evans… - Environmental …, 2024 - ACS Publications
Perfluoro-2-methoxyacetic acid (PFMOAA) is a short-chain perfluoroalkyl ether carboxylic
acid that has been detected at high concentrations (∼ 10 μg/L) in drinking water in eastern …

Exploring maternal and developmental toxicity of perfluoroalkyl ether acids PFO4DA and PFO5DoA using hepatic transcriptomics and serum metabolomics

TW Jackson, CS Lambright, N Evans… - Science of The Total …, 2024 - Elsevier
Production of per-and polyfluoroalkyl substances (PFAS) has shifted from long-chain
perfluoroalkyl acids to short-chain compounds and those with ether bonds in the carbon …

Toxicological mechanisms of emerging per-/poly-fluoroalkyl substances: Focusing on transcriptional activity and gene expression disruption

L Chen, Y **e, M Li, M Mortimer, F Li, LH Guo - Toxicology, 2023 - Elsevier
Environmental and human monitoring studies have witnessed increasing occurrence of
emerging per-/poly-fluoroalkyl substances (ePFASs) worldwide. Three classes of ePFASs …