This article provides a comprehensive overview of the pathology of multiple sclerosis (MS),
including recent insights into its molecular neuropathology and immunology. It shows that all …

Summary About 10–15% of patients with multiple sclerosis (MS) present with gradually
increasing neurological disability, a disorder known as primary-progressive multiple …

Focal demyelinated plaques in white matter, which are the hallmark of multiple sclerosis
pathology, only partially explain the patient's clinical deficits. We thus analysed global brain …

Multiple sclerosis (MS) has been classically regarded as a white matter disease. However,
recent histopathological studies have convincingly shown that grey matter regions are also …

Multiple sclerosis (MS), the most frequent demyelinating disease, is characterized by a
variable disease course. The majority of patients starts with relapsing remitting (RR) …

Neocortical demyelination in the forebrain has recently been identified as an important
pathological feature of multiple sclerosis (MS). Here we describe that the cerebellar cortex is …

BACKGROUND AND PURPOSE: Cortical lesions constitute a substantial part of the total
lesion load in multiple sclerosis (MS) brain. They have been related to neuropsychological …

Brain atrophy as determined by quantitative MRI can be used to characterize disease
progression in multiple sclerosis. Many studies have addressed white matter (WM) …

Magnetic resonance imaging (MRI) is often divided into structural MRI and functional MRI
(fMRI). The former is a widely used imaging technique in research as well as in clinical …

The aim of our study is to evaluate the extent and distribution of grey matter demyelinating
lesions in multiple sclerosis (MS), addressing also neuronal loss and synaptic loss. Whole …