Non-small-cell lung cancer
Non-small-cell lung cancer (NSCLC) is one of the most frequent cancer types and is
responsible for the majority of cancer-related deaths worldwide. The management of …
responsible for the majority of cancer-related deaths worldwide. The management of …
Lung cancer in patients who have never smoked—An emerging disease
J LoPiccolo, A Gusev, DC Christiani… - Nature Reviews Clinical …, 2024 - nature.com
Lung cancer is the most common cause of cancer-related deaths globally. Although smoking-
related lung cancers continue to account for the majority of diagnoses, smoking rates have …
related lung cancers continue to account for the majority of diagnoses, smoking rates have …
Lung adenocarcinoma promotion by air pollutants
A complete understanding of how exposure to environmental substances promotes cancer
formation is lacking. More than 70 years ago, tumorigenesis was proposed to occur in a two …
formation is lacking. More than 70 years ago, tumorigenesis was proposed to occur in a two …
[HTML][HTML] Pan-cancer proteogenomics connects oncogenic drivers to functional states
Cancer driver events refer to key genetic aberrations that drive oncogenesis; however, their
exact molecular mechanisms remain insufficiently understood. Here, our multi-omics pan …
exact molecular mechanisms remain insufficiently understood. Here, our multi-omics pan …
Transcriptome‐level discovery of survival‐associated biomarkers and therapy targets in non‐small‐cell lung cancer
B Győrffy - British Journal of Pharmacology, 2024 - Wiley Online Library
Abstract Background and Purpose Survival rate of patients with lung cancer has increased
by over 60% in the recent two decades. With longer survival, the identification of genes …
by over 60% in the recent two decades. With longer survival, the identification of genes …
Developmental mosaicism underlying EGFR-mutant lung cancer presenting with multiple primary tumors
Although the development of multiple primary tumors in smokers with lung cancer can be
attributed to carcinogen-induced field cancerization, the occurrence of multiple tumors at …
attributed to carcinogen-induced field cancerization, the occurrence of multiple tumors at …
A novel signature predicts prognosis and immunotherapy in lung adenocarcinoma based on cancer-associated fibroblasts
Q Ren, P Zhang, H Lin, Y Feng, H Chi… - Frontiers in …, 2023 - frontiersin.org
Background Extensive research has established the significant correlations between cancer-
associated fibroblasts (CAFs) and various stages of cancer development, including initiation …
associated fibroblasts (CAFs) and various stages of cancer development, including initiation …
Early immune pressure initiated by tissue-resident memory T cells sculpts tumor evolution in non-small cell lung cancer
Tissue-resident memory T (T RM) cells provide immune defense against local infection and
can inhibit cancer progression. However, it is unclear to what extent chronic inflammation …
can inhibit cancer progression. However, it is unclear to what extent chronic inflammation …
Distinct immune microenvironment of lung adenocarcinoma in never-smokers from smokers
W Luo, Z Zeng, Y **, L Yang, T Fan, Z Wang, Y Pan… - Cell Reports …, 2023 - cell.com
Lung cancer in never-smokers (LCINS) presents clinicopathological and molecular features
distinct from that in smokers. Tumor microenvironment (TME) plays important roles in cancer …
distinct from that in smokers. Tumor microenvironment (TME) plays important roles in cancer …
Rate of pathogenic germline variants in patients with lung cancer
S Sorscher, J LoPiccolo, B Heald, E Chen… - JCO Precision …, 2023 - ascopubs.org
PURPOSE Germline genetic testing (GGT) is now recommended for all patients diagnosed
with ovarian or pancreatic cancer and for a large proportion of patients based solely on a …
with ovarian or pancreatic cancer and for a large proportion of patients based solely on a …