The field of ion mobility-mass spectrometry (IM-MS) has grown with significant momentum in
recent years in both fundamental advances and pioneering applications. A search of the …

Highlights•Collision induced unfolding (CIU) uses gas phase activation to probe
biomolecules.•CIU can detect subtle changes in protein structure, stability or …

Improvements in the performance and availability of commercial instrumentation have made
ion mobility-mass spectrometry (IM-MS) an increasingly popular approach for the structural …

Trapped ion mobility spectrometry (TIMS) is a relatively new gas-phase separation method
that has been coupled to quadrupole orthogonal acceleration time-of-flight mass …

Key Developments for Faster, More Precise Detection Capabilities Driven by the demand for
the rapid and advanced detection of explosives, chemical and biological warfare agents …

Mass spectrometry (MS)-based proteomics is emerging as a broadly effective means for
identification, characterization, and quantification of proteins that are integral components of …

A combined data acquisition and data processing strategy for improving the sensitivity and
resolution of ion mobility measurements is described. This strategy is implemented on a …

In the present work we describe the principles of operation, versatility and applicability of a
trapped ion mobility spectrometer (TIMS) analyzer for fast, gas-phase separation of …

Soils, sediments, freshwaters, and marine waters contain natural organic matter (NOM), an
exceedingly complex mixture of organic compounds that collectively exhibit a nearly …

Although nonnative protein conformations, including intermediates along the folding
pathway and kinetically trapped misfolded species that disfavor the native state, are rarely …