Defeating Alzheimer's disease and other dementias: a priority for European science and society

B Winblad, P Amouyel, S Andrieu, C Ballard… - The Lancet …, 2016 - thelancet.com
Executive summary Alzheimer's disease (AD) is the leading cause of dementia, and
because the primary risk factor for AD is old age, the prevalence of the disease is increasing …

Amsterdam dementia cohort: performing research to optimize care

WM Van Der Flier, P Scheltens - Journal of Alzheimer's …, 2018 - content.iospress.com
The Alzheimer center of the VU University Medical Center opened in 2000 and was initiated
to combine both patient care and research. Together, to date, all patients forming the …

Safety and efficacy of semorinemab in individuals with prodromal to mild Alzheimer disease: a randomized clinical trial

E Teng, PT Manser, K Pickthorn, F Brunstein… - JAMA …, 2022 - jamanetwork.com
Importance Neurofibrillary tangles composed of aggregated tau protein are one of the
neuropathological hallmarks of Alzheimer disease (AD) and correlate with clinical disease …

Optimizing patient care and research: the Amsterdam Dementia Cohort

WM van der Flier, YAL Pijnenburg… - Journal of …, 2014 - content.iospress.com
Since its opening in 2000, patient care and research go hand in hand at the Alzheimer
center of the VU University Medical Center, both organized in such a way that they mutually …

Cognitive and neuroimaging features and brain β-amyloidosis in individuals at risk of Alzheimer's disease (INSIGHT-preAD): a longitudinal observational study

B Dubois, S Epelbaum, F Nyasse, H Bakardjian… - The Lancet …, 2018 - thelancet.com
Background Improved understanding is needed of risk factors and markers of disease
progression in preclinical Alzheimer's disease. We assessed associations between brain β …

Computerized cognitive testing for older adults: a review

S Zygouris, M Tsolaki - American Journal of Alzheimer's …, 2015 - journals.sagepub.com
Objective: This article is a review of computerized tests and batteries used in the cognitive
assessment of older adults. Method: A literature search on Medline followed by cross …

Meaningful benefits: a framework to assess disease-modifying therapies in preclinical and early Alzheimer's disease

SS Assunção, RA Sperling, C Ritchie… - Alzheimer's research & …, 2022 - Springer
Background The need for preventive therapies that interrupt the progression of Alzheimer's
disease (AD) before the onset of symptoms or when symptoms are emerging is urgent and …

[HTML][HTML] Measuring cognition and function in the preclinical stage of Alzheimer's disease

S Weintraub, MC Carrillo, ST Farias… - Alzheimer's & Dementia …, 2018 - Elsevier
Abstract The Alzheimer's Association's Research Roundtable met in November 2016 to
explore how best to measure changes in cognition and function in the preclinical stage of …

European prevention of Alzheimer's dementia longitudinal cohort study (EPAD LCS): study protocol

A Solomon, M Kivipelto, JL Molinuevo, B Tom… - BMJ open, 2018 - bmjopen.bmj.com
Introduction The European Prevention of Alzheimer's Dementia (EPAD) project is funded
initially by the Innovative Medicines Initiative and has been established to overcome the …

[HTML][HTML] Detecting functional decline from normal aging to dementia: development and validation of a short version of the Amsterdam IADL Questionnaire

RJ Jutten, CFW Peeters, SMJ Leijdesdorff… - Alzheimer's & Dementia …, 2017 - Elsevier
Introduction Detecting functional decline from normal aging to dementia is relevant for
diagnostic and prognostic purposes. Therefore, the Amsterdam IADL Questionnaire (A-IADL …