Neutrophils are major effectors and regulators of the immune system. They play critical roles
not only in the eradication of pathogens but also in cancer initiation and progression …

Uncontrolled inflammation is a leading cause of many clinically relevant diseases. Current
therapeutic strategies focus mainly on immunosuppression rather than on the mechanisms …

Resolving-type macrophages prevent chronic inflammation by clearing apoptotic cells
through efferocytosis. These macrophages are thought to rely mainly on oxidative …

Neutrophils (also named polymorphonuclear leukocytes or PMN) are essential components
of the immune system, rapidly recruited to sites of inflammation, providing the first line of …

For more than 70 years, glucocorticoids (GCs) have been a powerful and affordable
treatment option for inflammatory diseases. However, their benefits do not come without a …

Most tissues are populated by macrophages, a cell type endowed with both immune and
nonimmune tasks that preserve tissue integrity and proper function. Within different tissues …

Understanding the circuits that promote an efficient resolution of inflammation is crucial to
deciphering the molecular and cellular processes required to promote tissue repair …

Phagoptosis, also called primary phagocytosis, is a recently recognised form of cell death
caused by phagocytosis of viable cells, resulting in their destruction. It is provoked by …

N-formyl peptide receptors (FPRs) are critical regulators of host defense in phagocytes and
are also expressed in epithelia. FPR signaling and function have been extensively studied …

Inflammation is a beneficial host reaction to tissue damage and has the essential primary
purpose of restoring tissue homeostasis. Inflammation plays a major role in containing and …