RNA is a key regulator of almost every cellular process, and the structures adopted by RNA
molecules are thought to be central to their functions. The recent fast-paced evolution of high …

Beyond transferring genetic information, RNAs are molecules with diverse functions that
include catalyzing biochemical reactions and regulating gene expression. Most of these …

Circular RNAs (circRNAs) produced from back-splicing of exons of pre-mRNAs are widely
expressed, but current understanding of their functions is limited. These RNAs are stable in …

The development of high-throughput RNA structure profiling methods in the past decade has
greatly facilitated our ability to map and characterize different aspects of RNA structures …

Cellular RNAs are heterogeneous with respect to their alternative processing and secondary
structures, but the functional importance of this complexity is still poorly understood. A set of …

SARS-CoV-2 is a betacoronavirus with a linear single-stranded, positive-sense RNA
genome, whose outbreak caused the ongoing COVID-19 pandemic. The ability of …

RNA polymerase I (Pol I) transcription takes place at the border of the fibrillar center (FC)
and the dense fibrillar component (DFC) in the nucleolus. Here, we report that individual …

Translational reprogramming allows organisms to adapt to changing conditions. Upstream
start codons (uAUGs), which are prevalently present in mRNAs, have crucial roles in …

Flaviviruses, such as dengue, Japanese encephalitis, tick-borne encephalitis, West Nile,
yellow fever, and Zika viruses, are critically important human pathogens that sicken a …

Precursor messenger RNA (pre-mRNA) splicing is a critical step in the posttranscriptional
regulation of gene expression, providing significant expansion of the functional proteome of …