Until only a few years ago, single-particle electron cryo-microscopy (cryo-EM) was usually
not the first choice for many structural biologists due to its limited resolution in the range of …

The adeno-associated virus (AAV) is a small, nonpathogenic parvovirus, which depends on
helper factors to replicate. Those helper factors can be provided by coinfecting helper …

The three-dimensional reconstruction of the bovine kidney pyruvate dehydrogenase
complex (M r≈ 7.8× 106) comprising about 22 molecules of pyruvate dehydrogenase (E1) …

A computational procedure is described for assigning the absolute hand of the structure of a
protein or assembly determined by single-particle electron microscopy. The procedure …

This Meeting Review describes the proceedings and conclusions from the inaugural
meeting of the Electron Microscopy Validation Task Force organized by the Unified Data …

We review approaches aimed at deciphering the physical mechanisms responsible for viral
structure and assembly. We discuss the basic principles of condensed matter physics …

Herpesviruses are enveloped viruses that are prevalent in the human population and are
responsible for diverse pathologies, including cold sores, birth defects and cancers. They …

Herpes simplex virus, a DNA virus of high complexity, consists of a nucleocapsid
surrounded by the tegument—a protein compartment—and the envelope. The latter …

Herpesviruses comprise an abundant, widely distributed group of large DNA viruses of
humans and other vertebrates, and overall are among the most extensively studied large …

INTRODUCTION Since Hippocrates first described the cutaneous spreading of herpes
simplex lesions, many other diseases—chickenpox, infectious mononucleosis …