Unravelling tumour heterogeneity by single-cell profiling of circulating tumour cells
Single-cell technologies have contributed to unravelling tumour heterogeneity, now
considered a hallmark of cancer and one of the main causes of tumour resistance to cancer …
considered a hallmark of cancer and one of the main causes of tumour resistance to cancer …
[HTML][HTML] The amoeboid state as part of the epithelial-to-mesenchymal transition programme
V Graziani, I Rodriguez-Hernandez, O Maiques… - Trends in cell …, 2022 - cell.com
Cell migration is essential for many biological processes, while abnormal cell migration is
characteristic of cancer cells. Epithelial cells become motile by undergoing epithelial-to …
characteristic of cancer cells. Epithelial cells become motile by undergoing epithelial-to …
Integration of actin dynamics and cell adhesion by a three-dimensional, mechanosensitive molecular clutch
During cell migration, the forces generated in the actin cytoskeleton are transmitted across
transmembrane receptors to the extracellular matrix or other cells through a series of …
transmembrane receptors to the extracellular matrix or other cells through a series of …
[HTML][HTML] Anoikis molecular pathways and its role in cancer progression
Anoikis is a programmed cell death induced upon cell detachment from extracellular matrix,
behaving as a critical mechanism in preventing adherent-independent cell growth and …
behaving as a critical mechanism in preventing adherent-independent cell growth and …
[HTML][HTML] Cancer invasion and the microenvironment: plasticity and reciprocity
Cancer invasion is a cell-and tissue-driven process for which the physical, cellular, and
molecular determinants adapt and react throughout the progression of the disease. Cancer …
molecular determinants adapt and react throughout the progression of the disease. Cancer …
Cancer invasion: patterns and mechanisms
NV Krakhmal, MV Zavyalova, EV Denisov… - Acta Naturae …, 2015 - cyberleninka.ru
Cancer invasion and the ability of malignant tumor cells for directed migration and
metastasis have remained a focus of research for many years. Numerous studies have …
metastasis have remained a focus of research for many years. Numerous studies have …
The matrix environmental and cell mechanical properties regulate cell migration and contribute to the invasive phenotype of cancer cells
CT Mierke - Reports on Progress in Physics, 2019 - iopscience.iop.org
The minimal structural unit of a solid tumor is a single cell or a cellular compartment such as
the nucleus. A closer look inside the cells reveals that there are functional compartments or …
the nucleus. A closer look inside the cells reveals that there are functional compartments or …
Multifunctional nanostructured PLA materials for packaging and tissue engineering
This review reports the promising prospects of poly (lactic acid)(PLA) based nanostructured
materials considering two of their main potential uses, packaging and tissue engineering …
materials considering two of their main potential uses, packaging and tissue engineering …
TGF-β signaling and epithelial–mesenchymal transition in cancer progression
The differentiation plasticity of epithelial cells that mediates TGF-β-induced EMT and
reversion from mesenchymal to epithelial phenotype are increasingly seen as integral …
reversion from mesenchymal to epithelial phenotype are increasingly seen as integral …
Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation
M Vinci, S Gowan, F Boxall, L Patterson… - BMC biology, 2012 - Springer
Background There is overwhelming evidence that in vitro three-dimensional tumor cell
cultures more accurately reflect the complex in vivo microenvironment than simple two …
cultures more accurately reflect the complex in vivo microenvironment than simple two …