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Advances and opportunities in malaria population genomics
Almost 20 years have passed since the first reference genome assemblies were published
for Plasmodium falciparum, the deadliest malaria parasite, and Anopheles gambiae, the …
for Plasmodium falciparum, the deadliest malaria parasite, and Anopheles gambiae, the …
Challenges for malaria elimination in Brazil
Brazil currently contributes 42% of all malaria cases reported in the Latin America and the
Caribbean, a region where major progress towards malaria elimination has been achieved …
Caribbean, a region where major progress towards malaria elimination has been achieved …
Lineage-informative microhaplotypes for recurrence classification and spatio-temporal surveillance of Plasmodium vivax malaria parasites
Challenges in classifying recurrent Plasmodium vivax infections constrain surveillance of
antimalarial efficacy and transmission. Recurrent infections may arise from activation of …
antimalarial efficacy and transmission. Recurrent infections may arise from activation of …
Population genomics studies identify signatures of global dispersal and drug resistance in Plasmodium vivax
Plasmodium vivax is a major public health burden, responsible for the majority of malaria
infections outside Africa. We explored the impact of demographic history and selective …
infections outside Africa. We explored the impact of demographic history and selective …
Genomic analysis of local variation and recent evolution in Plasmodium vivax
The widespread distribution and relapsing nature of Plasmodium vivax infection present
major challenges for the elimination of malaria. To characterize the genetic diversity of this …
major challenges for the elimination of malaria. To characterize the genetic diversity of this …
Molecular markers for malaria genetic epidemiology: progress and pitfalls
Over recent years, progress in molecular markers for genoty** malaria parasites has
enabled informative studies of epidemiology and transmission dynamics. Results have …
enabled informative studies of epidemiology and transmission dynamics. Results have …
Sensitive, Highly Multiplexed Sequencing of Microhaplotypes From the Plasmodium falciparum Heterozygome
Background Targeted next-generation sequencing offers the potential for consistent, deep
coverage of information-rich genomic regions to characterize polyclonal Plasmodium …
coverage of information-rich genomic regions to characterize polyclonal Plasmodium …
Malaria molecular surveillance in the Peruvian Amazon with a novel highly multiplexed Plasmodium falciparum AmpliSeq assay
Molecular surveillance for malaria has great potential to support national malaria control
programs (NMCPs). To bridge the gap between research and implementation, several …
programs (NMCPs). To bridge the gap between research and implementation, several …
Design and implementation of multiplexed amplicon sequencing panels to serve genomic epidemiology of infectious disease: a malaria case study
Multiplexed PCR amplicon sequencing (AmpSeq) is an increasingly popular application for
cost‐effective monitoring of threatened species and managed wildlife populations, and …
cost‐effective monitoring of threatened species and managed wildlife populations, and …
Molecular approaches to determine the multiplicity of Plasmodium infections
Multiplicity of infection (MOI), also termed complexity of infection (COI), is defined as the
number of genetically distinct parasite strains co-infecting a single host, which is an …
number of genetically distinct parasite strains co-infecting a single host, which is an …