Advances and opportunities in malaria population genomics

DE Neafsey, AR Taylor, BL MacInnis - Nature Reviews Genetics, 2021 - nature.com
Almost 20 years have passed since the first reference genome assemblies were published
for Plasmodium falciparum, the deadliest malaria parasite, and Anopheles gambiae, the …

Challenges for malaria elimination in Brazil

MU Ferreira, MC Castro - Malaria journal, 2016 - Springer
Brazil currently contributes 42% of all malaria cases reported in the Latin America and the
Caribbean, a region where major progress towards malaria elimination has been achieved …

Lineage-informative microhaplotypes for recurrence classification and spatio-temporal surveillance of Plasmodium vivax malaria parasites

SV Siegel, H Trimarsanto, R Amato, K Murie… - Nature …, 2024 - nature.com
Challenges in classifying recurrent Plasmodium vivax infections constrain surveillance of
antimalarial efficacy and transmission. Recurrent infections may arise from activation of …

Population genomics studies identify signatures of global dispersal and drug resistance in Plasmodium vivax

DN Hupalo, Z Luo, A Melnikov, PL Sutton, P Rogov… - Nature …, 2016 - nature.com
Plasmodium vivax is a major public health burden, responsible for the majority of malaria
infections outside Africa. We explored the impact of demographic history and selective …

Genomic analysis of local variation and recent evolution in Plasmodium vivax

RD Pearson, R Amato, S Auburn, O Miotto… - Nature …, 2016 - nature.com
The widespread distribution and relapsing nature of Plasmodium vivax infection present
major challenges for the elimination of malaria. To characterize the genetic diversity of this …

Molecular markers for malaria genetic epidemiology: progress and pitfalls

S Ruybal-Pesántez, K McCann, J Vibin, S Siegel… - Trends in …, 2024 - cell.com
Over recent years, progress in molecular markers for genoty** malaria parasites has
enabled informative studies of epidemiology and transmission dynamics. Results have …

Sensitive, Highly Multiplexed Sequencing of Microhaplotypes From the Plasmodium falciparum Heterozygome

SK Tessema, NJ Hathaway, NB Teyssier… - The Journal of …, 2022 - academic.oup.com
Background Targeted next-generation sequencing offers the potential for consistent, deep
coverage of information-rich genomic regions to characterize polyclonal Plasmodium …

Malaria molecular surveillance in the Peruvian Amazon with a novel highly multiplexed Plasmodium falciparum AmpliSeq assay

JH Kattenberg, C Fernandez-Miñope… - Microbiology …, 2023 - journals.asm.org
Molecular surveillance for malaria has great potential to support national malaria control
programs (NMCPs). To bridge the gap between research and implementation, several …

Design and implementation of multiplexed amplicon sequencing panels to serve genomic epidemiology of infectious disease: a malaria case study

E LaVerriere, P Schwabl, M Carrasquilla… - Molecular Ecology …, 2022 - Wiley Online Library
Multiplexed PCR amplicon sequencing (AmpSeq) is an increasingly popular application for
cost‐effective monitoring of threatened species and managed wildlife populations, and …

Molecular approaches to determine the multiplicity of Plasmodium infections

D Zhong, C Koepfli, L Cui, G Yan - Malaria journal, 2018 - Springer
Multiplicity of infection (MOI), also termed complexity of infection (COI), is defined as the
number of genetically distinct parasite strains co-infecting a single host, which is an …