Ion channels are involved in a variety of fundamental physiological processes, and their
malfunction causes numerous human diseases. Therefore, ion channels represent a class of …

Peptides folded through interwoven disulfides display extreme biochemical properties and
unique medicinal potential. However, their exploitation has been hampered by the limited …

Although voltage-gated sodium channels (Na v) are the cellular target of paralytic shellfish
poisoning (PSP) toxins and that patch clamp electrophysiology is the most effective way of …

This unit provides an overview of the principal electrophysiological techniques commonly
used for the study of ionic currents and the ion channels that mediate them. These …

Introduction: There are currently many lead discovery platforms available for drug discovery.
Yet, it is often debated whether any of the available platforms are superior or standout to the …

Abstract The Family Smoking Prevention and Tobacco Control Act of 2009 (Public Law 111-
31) gave the US Food and Drug Administration (FDA) the responsibility for regulating …

Ligand gated ion channels are involved in many pathophysiological processes and
represent a relevant, although challenging, target for drug discovery. We propose an …

Patch-Clamp electrophysiology, the “gold standard” for the functional study of ion channels
has become automated. This innovative technology, already over a decade old, has …

Voltage-gated calcium channels represent important drug targets. The implementation of
higher throughput electrophysiology assays is necessary to characterize the interaction of …

Voltage-gated sodium channels represent important drug targets. The implementation of
higher throughput electrophysiology assays is necessary to characterize the interaction of …