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Physiology and diseases of tissue-resident macrophages
Embryo-derived tissue-resident macrophages are the first representatives of the
haematopoietic lineage to emerge in metazoans. In mammals, resident macrophages …
haematopoietic lineage to emerge in metazoans. In mammals, resident macrophages …
[HTML][HTML] Wound healing, fibroblast heterogeneity, and fibrosis
Fibroblasts are highly dynamic cells that play a central role in tissue repair and fibrosis.
However, the mechanisms by which they contribute to both physiologic and pathologic …
However, the mechanisms by which they contribute to both physiologic and pathologic …
Profiling cell identity and tissue architecture with single-cell and spatial transcriptomics
Single-cell transcriptomics has broadened our understanding of cellular diversity and gene
expression dynamics in healthy and diseased tissues. Recently, spatial transcriptomics has …
expression dynamics in healthy and diseased tissues. Recently, spatial transcriptomics has …
[HTML][HTML] Deciphering cell states and genealogies of human haematopoiesis
The human blood system is maintained through the differentiation and massive amplification
of a limited number of long-lived haematopoietic stem cells (HSCs). Perturbations to this …
of a limited number of long-lived haematopoietic stem cells (HSCs). Perturbations to this …
[HTML][HTML] Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution
Tumor evolution is driven by the progressive acquisition of genetic and epigenetic
alterations that enable uncontrolled growth and expansion to neighboring and distal tissues …
alterations that enable uncontrolled growth and expansion to neighboring and distal tissues …
[HTML][HTML] MDSC: Markers, development, states, and unaddressed complexity
Myeloid-derived suppressor cells (MDSCs) are one of the most discussed biological entities
in immunology. While the context and classification of this group of cells has evolved …
in immunology. While the context and classification of this group of cells has evolved …
A mouse model with high clonal barcode diversity for joint lineage, transcriptomic, and epigenomic profiling in single cells
Cellular lineage histories and their molecular states encode fundamental principles of tissue
development and homeostasis. Current lineage-recording mouse models have insufficient …
development and homeostasis. Current lineage-recording mouse models have insufficient …
Lineage tracing meets single-cell omics: opportunities and challenges
A fundamental goal of developmental and stem cell biology is to map the developmental
history (ontogeny) of differentiated cell types. Recent advances in high-throughput single …
history (ontogeny) of differentiated cell types. Recent advances in high-throughput single …
Lifelong multilineage contribution by embryonic-born blood progenitors
Haematopoietic stem cells (HSCs) arise in the embryo from the arterial endothelium through
a process known as the endothelial-to-haematopoietic transition (EHT),,–. This process …
a process known as the endothelial-to-haematopoietic transition (EHT),,–. This process …
Characterization of cell fate probabilities in single-cell data with Palantir
Single-cell RNA sequencing studies of differentiating systems have raised fundamental
questions regarding the discrete versus continuous nature of both differentiation and cell …
questions regarding the discrete versus continuous nature of both differentiation and cell …