Challenges and opportunities in sharing microbiome data and analyses

C Huttenhower, RD Finn, AC McHardy - Nature Microbiology, 2023 - nature.com
Microbiome data, metadata and analytical workflows have become 'big'in terms of volume
and complexity. Although the infrastructure and technologies to share data have been …

Gut microbes and the brain: paradigm shift in neuroscience

EA Mayer, R Knight, SK Mazmanian… - Journal of …, 2014 - Soc Neuroscience
The discovery of the size and complexity of the human microbiome has resulted in an
ongoing reevaluation of many concepts of health and disease, including diseases affecting …

FungalTraits: a user-friendly traits database of fungi and fungus-like stramenopiles

S Põlme, K Abarenkov, R Henrik Nilsson, BD Lindahl… - Fungal diversity, 2020 - Springer
The cryptic lifestyle of most fungi necessitates molecular identification of the guild in
environmental studies. Over the past decades, rapid development and affordability of …

Pathogen-induced activation of disease-suppressive functions in the endophytic root microbiome

VJ Carrión, J Perez-Jaramillo, V Cordovez, V Tracanna… - Science, 2019 - science.org
Microorganisms living inside plants can promote plant growth and health, but their genomic
and functional diversity remain largely elusive. Here, metagenomics and network inference …

[PDF][PDF] QIIME 2: Reproducible, interactive, scalable, and extensible microbiome data science

E Bolyen, JR Rideout, MR Dillon, NA Bokulich, C Abnet… - 2018 - peerj.com
We present QIIME 2, an opensource microbiome data science platform accessible to users
spanning the microbiome research ecosystem, from scientists and engineers to clinicians …

Reproducible molecular networking of untargeted mass spectrometry data using GNPS

AT Aron, EC Gentry, KL McPhail, LF Nothias… - Nature protocols, 2020 - nature.com
Abstract Global Natural Product Social Molecular Networking (GNPS) is an interactive online
small molecule–focused tandem mass spectrometry (MS2) data curation and analysis …

Establishing microbial composition measurement standards with reference frames

JT Morton, C Marotz, A Washburne, J Silverman… - Nature …, 2019 - nature.com
Differential abundance analysis is controversial throughout microbiome research. Gold
standard approaches require laborious measurements of total microbial load, or absolute …

Regional variation limits applications of healthy gut microbiome reference ranges and disease models

Y He, W Wu, HM Zheng, P Li, D McDonald, HF Sheng… - Nature medicine, 2018 - nature.com
Dysbiosis, departure of the gut microbiome from a healthy state, has been suggested to be a
powerful biomarker of disease incidence and progression,–. Diagnostic applications have …

Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2

E Bolyen, JR Rideout, MR Dillon, NA Bokulich… - Nature …, 2019 - nature.com
To the Editor—Rapid advances in DNA-sequencing and bioinformatics technologies in the
past two decades have substantially improved understanding of the microbial world. This …

A communal catalogue reveals Earth's multiscale microbial diversity

LR Thompson, JG Sanders, D McDonald, A Amir… - Nature, 2017 - nature.com
Our growing awareness of the microbial world's importance and diversity contrasts starkly
with our limited understanding of its fundamental structure. Despite recent advances in DNA …