Electroporation-based technologies for medicine: principles, applications, and challenges
When high-amplitude, short-duration pulsed electric fields are applied to cells and tissues,
the permeability of the cell membranes and tissue is increased. This increase in permeability …
the permeability of the cell membranes and tissue is increased. This increase in permeability …
A review of basic to clinical studies of irreversible electroporation therapy
C Jiang, RV Davalos, JC Bischof - IEEE Transactions on …, 2014 - ieeexplore.ieee.org
The use of irreversible electroporation (IRE) for cancer treatment has increased sharply over
the past decade. As a nonthermal therapy, IRE offers several potential benefits over other …
the past decade. As a nonthermal therapy, IRE offers several potential benefits over other …
Selective modulation of intracellular effects of cells using pulsed electric fields
A system and method for selectively treating aberrant cells such as cancer cells through
administration of a train of electrical pulses is described. The pulse length and delay …
administration of a train of electrical pulses is described. The pulse length and delay …
Irreversible electroporation: background, theory, and review of recent developments in clinical oncology
KN Aycock, RV Davalos - Bioelectricity, 2019 - liebertpub.com
Irreversible electroporation (IRE) has established a clinical niche as an alternative to thermal
ablation for the eradication of unresectable tumors, particularly those near critical vascular …
ablation for the eradication of unresectable tumors, particularly those near critical vascular …
High-frequency irreversible electroporation (H-FIRE) for non-thermal ablation without muscle contraction
Background Therapeutic irreversible electroporation (IRE) is an emerging technology for the
non-thermal ablation of tumors. The technique involves delivering a series of unipolar …
non-thermal ablation of tumors. The technique involves delivering a series of unipolar …
Synthesis and cellular uptake of folic acid-conjugated cellulose nanocrystals for cancer targeting
Elongated nanoparticles have recently been shown to have distinct advantages over
spherical ones in targeted drug delivery applications. In addition to their oblong geometry …
spherical ones in targeted drug delivery applications. In addition to their oblong geometry …
Low vulnerability of the right phrenic nerve to electroporation ablation
VJHM van Driel, K Neven, H van Wessel, A Vink… - Heart Rhythm, 2015 - Elsevier
Background Circular electroporation ablation is a novel ablation modality for electrical
pulmonary vein isolation. With a single 200-J application, deep circular myocardial lesions …
pulmonary vein isolation. With a single 200-J application, deep circular myocardial lesions …
A numerical investigation of the electric and thermal cell kill distributions in electroporation-based therapies in tissue
Electroporation-based therapies are powerful biotechnological tools for enhancing the
delivery of exogeneous agents or killing tissue with pulsed electric fields (PEFs) …
delivery of exogeneous agents or killing tissue with pulsed electric fields (PEFs) …
Microsecond and nanosecond electric pulses in cancer treatments
M Breton, LM Mir - Bioelectromagnetics, 2012 - Wiley Online Library
New local treatments based on electromagnetic fields have been developed as non‐
surgical and minimally invasive treatments of tumors. In particular, short electric pulses can …
surgical and minimally invasive treatments of tumors. In particular, short electric pulses can …
Integration of very short electric pulses for minimally to noninvasive electroporation
R Davalos, B Christopher, J Caldwell - US Patent 8,926,606, 2015 - Google Patents
The present invention provides methods, devices, and sys tems for in vivo treatment of cell
proliferative disorders. The invention can be used to treat solid tumors, such as brain tumors …
proliferative disorders. The invention can be used to treat solid tumors, such as brain tumors …