Primary cilia support cartilage regeneration after injury

D Tao, L Zhang, Y Ding, N Tang, X Xu, G Li… - International Journal of …, 2023 - nature.com
In growing children, growth plate cartilage has limited self-repair ability upon fracture injury
always leading to limb growth arrest. Interestingly, one type of fracture injuries within the …

Recent advances in primary cilia in bone metabolism

F Lian, H Li, Y Ma, R Zhou, W Wu - Frontiers in Endocrinology, 2023 - frontiersin.org
Primary cilia are microtubule-based organelles that are widespread on the cell surface and
play a key role in tissue development and homeostasis by sensing and transducing various …

Enpp1 mutations promote upregulation of hedgehog signaling in heterotopic ossification with aging

Z He, Z Zhu, T Tang, F Wang, P Guo, J Li… - Journal of Bone and …, 2024 - Springer
Introduction Heterotopic ossification of the tendon and ligament (HOTL) is a chronic
progressive disease that is usually accompanied by thickening and ossification of ligaments …

Distinct expression patterns of Hedgehog signaling components in mouse gustatory system during postnatal tongue development and adult homeostasis

A Kumari, NE Franks, L Li, G Audu, S Liskowicz… - Plos one, 2024 - journals.plos.org
The Hedgehog (HH) pathway regulates embryonic development of anterior tongue taste
fungiform papilla (FP) and the posterior circumvallate (CVP) and foliate (FOP) taste papillae …

[HTML][HTML] High expression of TTC21A predict poor prognosis of colorectal cancer and influence the immune infiltrating level

N Li, Z Zhou, L Zhang, H Tang, X Chen… - Translational Cancer …, 2022 - ncbi.nlm.nih.gov
Background Colorectal cancer (CRC) is the third most common malignancy.
Immunoinvasion of tumor microenvironment was positively correlated with overall cancer …

The Skeletal Ciliopathies

I Collins, AKT Wann - The Extracellular Matrix in Genetic Skeletal …, 2024 - Springer
Within the broad and growing spectrum of human ciliopathies is a range of linked and
overlap** disorders that present with skeletal features. These have been coined the …

Genetic Interaction of Thm2 and Thm1 Shapes Postnatal Craniofacial Bone

EE Bumann, P Hahn Leat, HH Wang… - Journal of …, 2022 - mdpi.com
Ciliopathies are genetic syndromes that link skeletal dysplasias to the dysfunction of primary
cilia. Primary cilia are sensory organelles synthesized by intraflagellar transport (IFT)—A …