Evidence has revealed that transcription factors play essential roles in regulation of multiple
cellular processes, including cell proliferation, metastasis, EMT, cancer stem cells and …

Ubiquitination and deubiquitylation are pivotal posttranslational modifications essential for
regulating cellular protein homeostasis and are implicated in the development of human …

USP7, a ubiquitin-specific peptidase (USP), plays an important role in many cellular
processes through its catalytic deubiquitination of various substrates. However, its nuclear …

Abstract Ubiquitin-specific protease 3 (USP3), a kind of cysteine protease, is a crucial family
member of deubiquitinating enzymes. USP3 is aberrantly expressed in several tumors …

Capsaicin (CAP) is a well‐known anti‐cancer agent. Recently, we reported capsaicin‐
induced apoptosis in anaplastic thyroid cancer (ATC) cells. It is well accepted that the …

Background Randall's plaques (RP) are identified as anchored sites for kidney calcium
oxalate stones, but the mechanism remains unclear. Given the importance of osteogenic-like …

Intracellular proteins take part in almost every body function; thus, protein homeostasis is of
utmost importance. The ubiquitin proteasome system (UPS) has a fundamental role in …

In mammals, hearing loss is irreversible due to the lack of the regenerative capacity of the
auditory epithelium. However, stem/progenitor cells in mammalian cochleae may be a …

The hypoxia-inducible factor (HIF)-mediated hypoxia signaling pathway influences oxygen
homeostasis in aerobic organisms. This pathway is regulated by several other pathways …

Pluripotent embryonic stem cells (ESCs) are derived from preimplantation blastocysts and
can differentiate into all types of somatic cells. More recently discovered induced pluripotent …