Long-range enhancer–promoter contacts in gene expression control
Spatiotemporal gene expression programmes are orchestrated by transcriptional
enhancers, which are key regulatory DNA elements that engage in physical contacts with …
enhancers, which are key regulatory DNA elements that engage in physical contacts with …
Methods for map** 3D chromosome architecture
R Kempfer, A Pombo - Nature Reviews Genetics, 2020 - nature.com
Determining how chromosomes are positioned and folded within the nucleus is critical to
understanding the role of chromatin topology in gene regulation. Several methods are …
understanding the role of chromatin topology in gene regulation. Several methods are …
The relationship between genome structure and function
Precise patterns of gene expression in metazoans are controlled by three classes of
regulatory elements: promoters, enhancers and boundary elements. During differentiation …
regulatory elements: promoters, enhancers and boundary elements. During differentiation …
The role of 3D genome organization in development and cell differentiation
Extrachromosomal DNA amplifications in cancer
Extrachromosomal DNA (ecDNA) amplification is an important driver alteration in cancer. It
has been observed in most cancer types and is associated with worse patient outcome. The …
has been observed in most cancer types and is associated with worse patient outcome. The …
Regulation of genome organization and gene expression by nuclear mechanotransduction
It is well established that cells sense chemical signals from their local microenvironment and
transduce them to the nucleus to regulate gene expression programmes. Although a number …
transduce them to the nucleus to regulate gene expression programmes. Although a number …