One of the open questions in RAS biology is the existence of RAS dimers and their role in
RAF dimerization and activation. The idea of RAS dimers arose from the discovery that RAF …

RAS and MYC rank amongst the most commonly altered oncogenes in cancer, with RAS
being the most frequently mutated and MYC the most amplified. The cooperative interplay …

Phosphoinositides play a crucial role in regulating many cellular functions, such as actin
dynamics, signaling, intracellular trafficking, membrane dynamics, and cell–matrix adhesion …

Abstract Small GTPases including Ras, Rho, Rab, Arf, and Ran are omnipresent molecular
switches in regulating key cellular functions. Their dysregulation is a therapeutic target for …

Oncogenic KRAS expression generates a metabolic dependency on aerobic glycolysis,
known as the Warburg effect. We report an effect of increased glycolytic flux that feeds into …

RAF family protein kinases are a key node in the RAS/RAF/MAP kinase pathway, the
signaling cascade that controls cellular proliferation, differentiation, and survival in response …

Health and disease are directly related to the RTK-RAS-MAPK signalling cascade. After
more than three decades of intensive research, understanding its spatiotemporal features is …

RAS proteins are conserved guanosine triphosphate (GTP) hydrolases (GTPases) that act
as molecular binary switches and play vital roles in numerous cellular processes. Upon GTP …

Here, we discuss the principles of allosteric activating mutations, propagation downstream of
the signals that they prompt, and allosteric drugs, with examples from the Ras signaling …

RAS proteins are small GTPases that regulate signalling networks that control cellular
proliferation and survival. They are frequently mutated in cancer and a commonly occurring …