Quantifying brain microstructure with diffusion MRI: Theory and parameter estimation

DS Novikov, E Fieremans, SN Jespersen… - NMR in …, 2019 - Wiley Online Library
We review, systematize and discuss models of diffusion in neuronal tissue, by putting them
into an overarching physical context of coarse‐graining over an increasing diffusion length …

Imaging brain microstructure with diffusion MRI: practicality and applications

DC Alexander, TB Dyrby, M Nilsson… - NMR in …, 2019 - Wiley Online Library
This article gives an overview of microstructure imaging of the brain with diffusion MRI and
reviews the state of the art. The microstructure‐imaging paradigm aims to estimate and map …

[HTML][HTML] Multi-compartment microscopic diffusion imaging

E Kaden, ND Kelm, RP Carson, MD Does… - NeuroImage, 2016 - Elsevier
This paper introduces a multi-compartment model for microscopic diffusion anisotropy
imaging. The aim is to estimate microscopic features specific to the intra-and extra-neurite …

Q-space trajectory imaging for multidimensional diffusion MRI of the human brain

CF Westin, H Knutsson, O Pasternak… - Neuroimage, 2016 - Elsevier
This work describes a new diffusion MR framework for imaging and modeling of
microstructure that we call q-space trajectory imaging (QTI). The QTI framework consists of …

[HTML][HTML] Connectome 2.0: Develo** the next-generation ultra-high gradient strength human MRI scanner for bridging studies of the micro-, meso-and macro …

SY Huang, T Witzel, B Keil, A Scholz, M Davids, P Dietz… - NeuroImage, 2021 - Elsevier
The first phase of the Human Connectome Project pioneered advances in MRI technology
for map** the macroscopic structural connections of the living human brain through the …

Noninvasive quantification of axon radii using diffusion MRI

J Veraart, D Nunes, U Rudrapatna, E Fieremans… - elife, 2020 - elifesciences.org
Axon caliber plays a crucial role in determining conduction velocity and, consequently, in the
timing and synchronization of neural activation. Noninvasive measurement of axon radii …

Design and validation of diffusion MRI models of white matter

IO Jelescu, MD Budde - Frontiers in physics, 2017 - frontiersin.org
Diffusion MRI is arguably the method of choice for characterizing white matter microstructure
in vivo. Over the typical duration of diffusion encoding, the displacement of water molecules …

[HTML][HTML] Challenges for biophysical modeling of microstructure

IO Jelescu, M Palombo, F Bagnato… - Journal of Neuroscience …, 2020 - Elsevier
The biophysical modeling efforts in diffusion MRI have grown considerably over the past 25
years. In this review, we dwell on the various challenges along the journey of bringing a …

[HTML][HTML] White matter microstructure across the adult lifespan: A mixed longitudinal and cross-sectional study using advanced diffusion models and brain-age …

D Beck, AMG de Lange, II Maximov, G Richard… - NeuroImage, 2021 - Elsevier
The macro-and microstructural architecture of human brain white matter undergoes
substantial alterations throughout development and ageing. Most of our understanding of …

Modelling white matter with spherical deconvolution: How and why?

F Dell'Acqua, JD Tournier - NMR in Biomedicine, 2019 - Wiley Online Library
Since the realization that diffusion MRI can probe the microstructural organization and
orientation of biological tissue in vivo and non‐invasively, a multitude of diffusion imaging …