'Stem-like' precursors are the fount to sustain persistent CD8+ T cell responses
D Zehn, R Thimme, E Lugli, GP de Almeida… - Nature …, 2022 - nature.com
Virus-specific CD8+ T cells that differentiate in the context of resolved versus persisting
infections exhibit divergent phenotypic and functional characteristics, which suggests that …
infections exhibit divergent phenotypic and functional characteristics, which suggests that …
Regulation of interferon‐γ during innate and adaptive immune responses
JR Schoenborn, CB Wilson - Advances in immunology, 2007 - Elsevier
Abstract Interferon‐γ (IFN‐γ) is crucial for immunity against intracellular pathogens and for
tumor control. However, aberrant IFN‐γ expression has been associated with a number of …
tumor control. However, aberrant IFN‐γ expression has been associated with a number of …
T-cell quality in memory and protection: implications for vaccine design
T cells mediate effector functions through a variety of mechanisms. Recently, multiparameter
flow cytometry has allowed a simultaneous assessment of the phenotype and multiple …
flow cytometry has allowed a simultaneous assessment of the phenotype and multiple …
T‐cell exhaustion: characteristics, causes and conversion
T‐cell exhaustion is characterized by the stepwise and progressive loss of T‐cell functions
and can culminate in the physical deletion of the responding cells. Exhaustion is well …
and can culminate in the physical deletion of the responding cells. Exhaustion is well …
Functional and genomic profiling of effector CD8 T cell subsets with distinct memory fates
An important question in memory development is understanding the differences between
effector CD8 T cells that die versus effector cells that survive and give rise to memory cells …
effector CD8 T cells that die versus effector cells that survive and give rise to memory cells …
Sha** and resha** CD8+ T-cell memory
The ability to develop and sustain populations of memory T cells after infection or
immunization is a hallmark of the adaptive immune response and a basis for protective …
immunization is a hallmark of the adaptive immune response and a basis for protective …
Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus
EJ Yager, M Ahmed, K Lanzer, TD Randall… - The Journal of …, 2008 - rupress.org
A diverse T cell repertoire is essential for a vigorous immune response to new infections,
and decreasing repertoire diversity has been implicated in the age-associated decline in …
and decreasing repertoire diversity has been implicated in the age-associated decline in …
Expression patterns of NKG2A, KIR, and CD57 define a process of CD56dim NK-cell differentiation uncoupled from NK-cell education
NK Björkström, P Riese, F Heuts… - Blood, The Journal …, 2010 - ashpublications.org
Natural killer (NK) cells are lymphocytes of the innate immune system that, following
differentiation from CD56bright to CD56dim cells, have been thought to retain fixed …
differentiation from CD56bright to CD56dim cells, have been thought to retain fixed …
Blood monocytes: distinct subsets, how they relate to dendritic cells, and their possible roles in the regulation of T‐cell responses
F Geissmann, C Auffray, R Palframan… - Immunology and cell …, 2008 - Wiley Online Library
Monocytes can have important effects on the polarization and expansion of lymphocytes and
may contribute to sha** primary and memory T‐cell responses in humans and mice …
may contribute to sha** primary and memory T‐cell responses in humans and mice …
[HTML][HTML] Reversal of autoimmunity by boosting memory-like autoregulatory T cells
Blunting autoreactivity without compromising immunity remains an elusive goal in the
treatment of autoimmunity. We show that progression to autoimmune diabetes results in the …
treatment of autoimmunity. We show that progression to autoimmune diabetes results in the …