Biologists have long appreciated natural variation in the nematode phylum. The
development of Caenorhabditis elegans as a model organism has provided a rich set of …

In the early 1990s, attempts to manipulate gene expression by researchers working in three
different fields resulted in unanticipated gene silencing. Rather than ignoring such results …

Background A surprising amount of developmental variation has been observed for
otherwise highly conserved features, a phenomenon known as developmental system drift …

While RNA interference (RNAi) has been deployed to facilitate gene function studies in
diverse helminths, parasitic nematodes appear variably susceptible. To test if this is due to …

Nematodes belong to one of the most diverse animal phyla. However, functional genomic
studies in nematodes, other than in a few species, have often been limited in their reliability …

Background The nematode Caenorhabditis elegans is able to take up external double-
stranded RNAs (dsRNAs) and mount an RNA interference response, leading to the …

General mechanisms by which Hox genes establish cell fates are known. However, a few
Hox effectors mediating cell behaviors have been identified. Here we found the first effector …

The conserved homeobox (Hox) gene cluster is neither conserved nor clustered in the
nematode Caenorhabditis elegans. Instead, C. elegans has a reduced and dispersed gene …

Large gaps in basement membrane (BM) occur during organ remodelling and cancer cell
invasion. Whether dividing cells, which temporarily reduce their attachment to BM, influence …

RNA interference (RNAi) has been used extensively in model organisms such as
Caenorhabditis elegans. Methods developed for RNAi in C. elegans have also been used in …