The fine balance between the secretion, composition, volume and turnover of cerebrospinal
fluid (CSF) is strictly regulated. However, during certain neurological diseases, this balance …

Transient receptor potential (TRP) channels are nonselective cationic channels that are
generally Ca2+ permeable and have a heterogeneous expression in the heart. In the …

Background Glaucoma, the leading cause of irreversible blindness worldwide, is a type of
retinal disease characterized by the selective death of retinal ganglion cells (RGCs) …

Background Parkinson's disease (PD) is a progressive neurodegenerative disorder. Its
molecular mechanism is still unclear, and pharmacological treatments are unsatisfactory …

The overload cytosolic free Ca2+ (cCa2+) influx-mediated excessive generation of oxidative
stress in the pathophysiological conditions induces neuronal and cellular injury via the …

It has been documented that Ca2+ overload and increased production of reactive oxygen
species play a significant role in reperfusion injury (RI) of cardiomyocytes …

Our previous study has indicated that tetrandrine (TET) can target miR-202-5p to repress the
activation of transient receptor potential vanilloid type 2 (TRPV2), eventually ameliorating …

The transient receptor potential vanilloid 4 (TRPV4) channel is a non-selective cation
channel that is mostly permeable to calcium (Ca2+), which participates in intracellular Ca2+ …

Cardioprotection encompasses a variety of strategies protecting the heart against
myocardial injury that occurs during and after inadequate blood supply to the heart during …

Transient receptor potential vanilloid 4 (TRPV4) is highly expressed in heart and vessels
and can be activated during myocardial ischemia/reperfusion (I/R). Recently, we found that …