Cinnamaldehyde, one of the active components derived from Cinnamon, has been used as
a natural flavorant and fragrance agent in kitchen and industry. Emerging studies have been …

Resveratrol (3, 5, 4'-trihydroxy-trans-stilbene) is a non-flavonoid polyphenol that may be
present in a limited number of foodstuffs such as grapes and red wine. Resveratrol has been …

Insulin resistance, the most important characteristic of the type 2 diabetes mellitus (T2DM), is
mostly caused by impairment in the insulin receptor (IR) signal transduction pathway …

Background Resveratrol is a natural compound suggested to have beneficial health effects.
However, people are consuming resveratrol for this reason without having the adequate …

Objectives Even with great advances in modern medicine and therapeutic agent
development, the search for effective antidiabetic drugs remains challenging. Coumarins are …

General overnutrition but also a diet rich in certain macronutrients, age, insulin resistance
and an impaired intestinal barrier function may be critical factors in the development of …

Alzheimer's disease (AD) is a risk factor for type 2 diabetes and vice versa, and a growing
body of evidence indicates that these diseases are connected both at epidemiological …

Endothelial dysfunction is a key feature of cardiovascular disorders associated with obesity
and diabetes. Several studies identified protein tyrosine phosphatase (PTP)-1B, a member …

Insulin resistance is a key pathological feature of type 2 diabetes and is characterized by
defects in signaling by the insulin receptor (IR) protein tyrosine kinase. The inhibition of …

Despite significant advances in current understanding of mechanisms of pathogenesis in
Alzheimer's disease (AD), attempts at drug development based on those discoveries have …