Biopolymer nanoparticles for nose-to-brain drug delivery: A new promising approach for the treatment of neurological diseases

N Montegiove, E Calzoni, C Emiliani… - Journal of Functional …, 2022 - mdpi.com
Diseases affecting the central nervous system (CNS) are among the most disabling and the
most difficult to cure due to the presence of the blood–brain barrier (BBB) which represents …

Remote activation of enzyme nanohybrids for cancer prodrug therapy controlled by magnetic heating

B Torres-Herrero, I Armenia, M Alleva, L Asín… - ACS …, 2023 - ACS Publications
Herein, we have developed nanohybrids (nHs) to remotely activate a therapeutic enzyme for
its use in Directed Enzyme Prodrug Therapy (DEPT). The coencapsulation of magnetic …

[HTML][HTML] Aloe Extracellular Vesicles as Carriers of Photoinducible Metabolites Exhibiting Cellular Phototoxicity

E Calzoni, A Bertoldi, A Cesaretti, HBR Alabed… - Cells, 2024 - mdpi.com
The growing interest in plant-origin active molecules with medicinal properties has led to a
revaluation of plants in the pharmaceutical field. Plant-derived extracellular vesicles …

Enzymes immobilized polymeric supports for wastewater treatment application: A short review

J Lim, Z Mohamad - Materials Today: Proceedings, 2022 - Elsevier
Micro-pollutants, with a growing number of hazardous contaminants being introduced into
both human and natural ecosystems, have become a major topic of rising environmental …

HexA-Enzyme Coated Polymer Nanoparticles for the Development of a Drug-Delivery System in the Treatment of Sandhoff Lysosomal Storage Disease

E Calzoni, A Cesaretti, N Montegiove… - Journal of Functional …, 2022 - mdpi.com
Lysosomal storage disorders (LSDs) are a set of metabolic diseases caused by mutations in
genes that are in charge of the production of lysosomal enzymes, resulting in the buildup of …

Evidence of Lysosomal β-Hexosaminidase Enzymatic Activity Associated with Extracellular Vesicles: Potential Applications for the Correction of Sandhoff Disease

E Calzoni, G Cerrotti, K Sagini, F Delo… - Journal of Functional …, 2024 - mdpi.com
Extracellular vesicles (EVs) can be isolated from biological fluids and cell culture medium.
Their nanometric dimension, relative stability, and biocompatibility have raised considerable …

[HTML][HTML] Microplastic and Extracellular Vesicle Interactions: Recent Studies on Human Health and Environment Risks

E Calzoni, N Montegiove, A Cesaretti, A Bertoldi… - Biophysica, 2024 - mdpi.com
Microplastics (MPs) are widespread environmental pollutants that have drawn significant
attention due to their possible health risks to humans and animals, as well as their extensive …

Chemo-Enzymatic Production of 4-Nitrophenyl-2-acetamido-2-deoxy-α-D-galactopyranoside Using Immobilized β-N-Acetylhexosaminidase

H Hronská, V Štefuca, E Ondrejková, M Bláhová… - Catalysts, 2022 - mdpi.com
α-Nitrophenyl derivatives of glycosides are convenient substrates used to detect and
characterize α-N-acetylgalactosaminidase. A new procedure combining chemical and …

Optimizing covalent immobilization of glucose oxidase and laccase on PV15 fluoropolymer-based bioelectrodes

N Montegiove, E Calzoni, D Pelosi… - Journal of Functional …, 2022 - mdpi.com
Enzymatic biofuel cells (EBCs) represent a promising technology for biosensors, biodevices,
and sustainable green energy applications, thanks to enzymes' high specificity and catalytic …